Detailed information of TA system TA240042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 999170..999940
• Replicon: chromosome
• Accession: NZ_CP094714
• Organism: Staphylococcus schleiferi strain IVB6176

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA72_RS04655
• Protein ID: WP_016425469.1
• Coordinates: 999788..999940 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: S2Y062
• Locus tag: MUA72_RS04650
• Protein ID: WP_016425470.1
• Coordinates: 999170..999769 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA72_RS04630 (MUA72_04620)	995033..996493	+	1461	WP_126496414.1	ABC transporter permease subunit	-
MUA72_RS04635 (MUA72_04625)	996486..997214	+	729	WP_167733053.1	amino acid ABC transporter ATP-binding protein	-
MUA72_RS04640 (MUA72_04630)	997390..998520	+	1131	WP_262569947.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA72_RS04645 (MUA72_04635)	998520..998990	+	471	WP_016425471.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA72_RS04650 (MUA72_04640)	999170..999769	+	600	WP_016425470.1	hypothetical protein	Antitoxin
MUA72_RS04655 (MUA72_04645)	999788..999940	+	153	WP_016425469.1	SAS053 family protein	Toxin
MUA72_RS04660 (MUA72_04650)	1000090..1000515	+	426	WP_016425468.1	hypothetical protein	-
MUA72_RS04665 (MUA72_04655)	1000687..1002072	+	1386	WP_126496425.1	class II fumarate hydratase	-
MUA72_RS04670 (MUA72_04660)	1002093..1003619	+	1527	WP_016425466.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-197)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5931.35 Da
• Isoelectric Point: 3.9615

>T240042 WP_016425469.1 NZ_CP094714:999788-999940 [Staphylococcus schleiferi]
MKDDQKQYENEMVEGFDDVVELGKEMEQISEKNDQDKLNQDHDADIRSDK

Nucleotide

• Length: 153 bp

>T240042 NZ_LS483480:358344-358703 [Haemophilus influenzae]
ATGTACGAGATTCTCCTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GATGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22182.12 Da
• Isoelectric Point: 5.5527

>AT240042 WP_016425470.1 NZ_CP094714:999170-999769 [Staphylococcus schleiferi]
MAMNFKIFKDAETVAKYTADILRKQLNNNPTSIVGVHLNEDQAPVLNFLKQDVDRHSVDFSQIHILDYDKQASFFKSLGV
PEKQVHEVPDDDNVESFIAHHAKTKDNKGKLTLQVLTIDENGQIGLPMNDAVMPAREIIVVVTGSNKAAQVQKLYEENGN
TSFIPSTLKTHRMVTVVLDEAAAQGLPDDVRAYFTSLYA

Nucleotide

• Length: 600 bp

>AT240042 NZ_LS483480:358696-358992 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTTCCTCTAAGGGTAAAAAATGCCTAA

Structures

Antitoxin

• AlphaFold DB: S2Y062