Detailed information of TA system TA240041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 849840..850364
• Replicon: chromosome
• Accession: NZ_CP094714
• Organism: Staphylococcus schleiferi strain IVB6176

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: S2X8B9
• Locus tag: MUA72_RS03830
• Protein ID: WP_016426488.1
• Coordinates: 850011..850364 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: S2XCM0
• Locus tag: MUA72_RS03825
• Protein ID: WP_016426487.1
• Coordinates: 849840..850010 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA72_RS03800 (MUA72_03790)	845768..846196	+	429	WP_167512901.1	PH domain-containing protein	-
MUA72_RS03805 (MUA72_03795)	846189..847703	+	1515	WP_155976489.1	PH domain-containing protein	-
MUA72_RS03810 (MUA72_03800)	847687..848208	+	522	WP_126496614.1	PH domain-containing protein	-
MUA72_RS03815 (MUA72_03805)	848205..848561	+	357	WP_016426485.1	holo-ACP synthase	-
MUA72_RS03820 (MUA72_03810)	848606..849754	+	1149	WP_262576521.1	alanine racemase	-
MUA72_RS03825 (MUA72_03815)	849840..850010	+	171	WP_016426487.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MUA72_RS03830 (MUA72_03820)	850011..850364	+	354	WP_016426488.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MUA72_RS03835 (MUA72_03825)	850423..851427	+	1005	WP_016426489.1	PP2C family protein-serine/threonine phosphatase	-
MUA72_RS03840 (MUA72_03830)	851506..851832	+	327	WP_016426490.1	anti-sigma factor antagonist	-
MUA72_RS03845 (MUA72_03835)	851834..852313	+	480	WP_167732819.1	anti-sigma B factor RsbW	-
MUA72_RS03850 (MUA72_03840)	852288..853058	+	771	WP_016426492.1	RNA polymerase sigma factor SigB	-
MUA72_RS03855 (MUA72_03845)	853645..854850	-	1206	WP_081635139.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13157.33 Da
• Isoelectric Point: 10.1660

>T240041 WP_016426488.1 NZ_CP094714:850011-850364 [Staphylococcus schleiferi]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEEKMKEVNYALGISLGLNMNHHK

Nucleotide

• Length: 354 bp

>T240041 NZ_LS483480:c300313-300005 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6370.00 Da
• Isoelectric Point: 3.9760

>AT240041 WP_016426487.1 NZ_CP094714:849840-850010 [Staphylococcus schleiferi]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNESHLLSDYKDD

Nucleotide

• Length: 171 bp

>AT240041 NZ_LS483480:c300609-300313 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGTTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Toxin

• AlphaFold DB: S2X8B9

Antitoxin

• AlphaFold DB: S2XCM0