Detailed information of TA system TA024004

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/HTH_26(antitoxin)
• Location: 1038786..1039894
• Replicon: chromosome
• Accession: NC_012926
• Organism: Streptococcus suis BM407

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: A0A0H3MV52
• Locus tag: SSUBM407_RS05085
• Protein ID: WP_012775607.1
• Coordinates: 1038786..1039655 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: SSUBM407_RS05090
• Protein ID: WP_000205227.1
• Coordinates: 1039670..1039894 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUBM407_RS05055	1035010..1035198	+	189	WP_079394308.1	cysteine-rich KTR domain-containing protein	-
SSUBM407_RS05065	1035371..1036234	-	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
SSUBM407_RS05070	1036267..1036950	-	684	WP_012775604.1	class I SAM-dependent methyltransferase	-
SSUBM407_RS05075	1037077..1037550	-	474	WP_012775605.1	dihydrofolate reductase	-
SSUBM407_RS05080	1037653..1038678	-	1026	WP_012775606.1	IS1595-like element ISSsu9 family transposase	-
SSUBM407_RS05085	1038786..1039655	-	870	WP_012775607.1	nucleotidyltransferase domain-containing protein	Toxin
SSUBM407_RS05090	1039670..1039894	-	225	WP_000205227.1	helix-turn-helix transcriptional regulator	Antitoxin
SSUBM407_RS05095	1040037..1040117	-	81	Protein_961	site-specific recombinase	-
SSUBM407_RS05100	1041609..1042247	+	639	WP_011922443.1	hypothetical protein	-
SSUBM407_RS05105	1042286..1043362	+	1077	WP_011922442.1	toprim domain-containing protein	-
SSUBM407_RS05110	1043416..1043643	+	228	WP_011922441.1	hypothetical protein	-
SSUBM407_RS05115	1043640..1044029	+	390	WP_011922440.1	methyl-accepting chemotaxis protein	-
SSUBM407_RS05120	1044079..1044369	+	291	WP_024379089.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / ant(6)-Ia / tet(M) / tet(L)	-	1032547..1125755	93208
	-	flank	IS/Tn	erm(B) / tet(O) / ant(6)-Ia	-	1031089..1038678	7589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32940.60 Da
• Isoelectric Point: 4.8781

>T24004 WP_012775607.1 NC_012926:c1039655-1038786 [Streptococcus suis BM407]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHIFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T24004 NC_012926:c1039655-1038786 [Streptococcus suis BM407]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATCGTATTAGGGGGCTC
ACGTGCAAGAGGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAATTGGATGATAAAAATAGAAACAACCTTGTTGTGCCTCCCGGAGCGTGGGGTGATTGG
ATTAATGGCGGCGGATGGTTATTTATAAATGGGTATCATGTTGACTTGATTTTACGTGATATAAAACGGGTAGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCAATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGTAGAGGATAAATATTATATTGCAGGCCATATTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGATATGACCGAGAAACTTTATAAAGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT24004 WP_000205227.1 NC_012926:c1039894-1039670 [Streptococcus suis BM407]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT24004 NC_012926:c1039894-1039670 [Streptococcus suis BM407]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCCATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGAAGAAATAAAAATATCTAACGAATAA

Structures

Toxin

• AlphaFold DB: A0A0H3MV52