Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 846568..847092 Replicon chromosome
Accession NZ_CP094713
Organism Staphylococcus schleiferi strain IVB6180

Toxin (Protein)


Gene name mazF Uniprot ID S2X8B9
Locus tag MUA91_RS03810 Protein ID WP_016426488.1
Coordinates 846739..847092 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S2XCM0
Locus tag MUA91_RS03805 Protein ID WP_016426487.1
Coordinates 846568..846738 (+) Length 57 a.a.

Genomic Context


MUA91_RS03780MUA91_RS03785MUA91_RS03790MUA91_RS03795MUA91_RS03800MUA91_RS03805MUA91_RS03810MUA91_RS03815MUA91_RS03820MUA91_RS03825MUA91_RS03830MUA91_RS03835
Location: 842496..842924 (429 bp)
Type: Others
Protein ID: WP_167512901.1
Location: 842917..844431 (1515 bp)
Type: Others
Protein ID: WP_155976489.1
Location: 844415..844936 (522 bp)
Type: Others
Protein ID: WP_126496614.1
Location: 844933..845289 (357 bp)
Type: Others
Protein ID: WP_016426485.1
Location: 845334..846482 (1149 bp)
Type: Others
Protein ID: WP_262569915.1
Location: 846568..846738 (171 bp)
Type: Antitoxin
Protein ID: WP_016426487.1
Location: 846739..847092 (354 bp)
Type: Toxin
Protein ID: WP_016426488.1
Location: 847151..848155 (1005 bp)
Type: Others
Protein ID: WP_262569916.1
Location: 848234..848560 (327 bp)
Type: Others
Protein ID: WP_016426490.1
Location: 848562..849041 (480 bp)
Type: Others
Protein ID: WP_167732819.1
Location: 849016..849786 (771 bp)
Type: Others
Protein ID: WP_016426492.1
Location: 850373..851578 (1206 bp)
Type: Others
Protein ID: WP_081635139.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MUA91_RS03780 (MUA91_03770)842496..842924+429WP_167512901.1PH domain-containing protein-
MUA91_RS03785 (MUA91_03775)842917..844431+1515WP_155976489.1PH domain-containing protein-
MUA91_RS03790 (MUA91_03780)844415..844936+522WP_126496614.1PH domain-containing protein-
MUA91_RS03795 (MUA91_03785)844933..845289+357WP_016426485.1holo-ACP synthase-
MUA91_RS03800 (MUA91_03790)845334..846482+1149WP_262569915.1alanine racemase-
MUA91_RS03805 (MUA91_03795)846568..846738+171WP_016426487.1type II toxin-antitoxin system antitoxin MazEAntitoxin
MUA91_RS03810 (MUA91_03800)846739..847092+354WP_016426488.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MUA91_RS03815 (MUA91_03805)847151..848155+1005WP_262569916.1PP2C family protein-serine/threonine phosphatase-
MUA91_RS03820 (MUA91_03810)848234..848560+327WP_016426490.1anti-sigma factor antagonist-
MUA91_RS03825 (MUA91_03815)848562..849041+480WP_167732819.1anti-sigma B factor RsbW-
MUA91_RS03830 (MUA91_03820)849016..849786+771WP_016426492.1RNA polymerase sigma factor SigB-
MUA91_RS03835 (MUA91_03825)850373..851578-1206WP_081635139.1IS110 family transposase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-108)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 118 a.a.        Molecular weight: 13157.33 Da        Isoelectric Point: 10.1660

>T240038 WP_016426488.1 NZ_CP094713:846739-847092 [Staphylococcus schleiferi]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEEKMKEVNYALGISLGLNMNHHK

Download         Length: 354 bp

>T240038 NZ_LS483476:736194-736544 [Lederbergia lentus]
TTGGCCGTAAAGCGTGGTGACGTGTATTTCGCCGACTTATCTCCAGTGGTCGGTTCAGAGCAAGGCGGCGTCCGGCCAGT
GCTGGTAATTCAGAATGATATTGGGAATCGTTTTAGCCCTACTGTAATTGTTGCTGCAATTACAGCACAGATACAAAAAG
CAAAACTGCCTACTCATGTGGAGATTGATTCTAAGCGTTATAGTTTTGAGAGAGACTCTGTGCTATTATTAGAACAAGTT
AGAACAATTGATAAGCAACGTTTAACAGACAAGATTACACATCTTGACGAAGAAATGATGAAAAAAGTAGATGAAGCCTT
ACAAATAAGTCTTGGACTCATCGATTTTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6370.00 Da        Isoelectric Point: 3.9760

>AT240038 WP_016426487.1 NZ_CP094713:846568-846738 [Staphylococcus schleiferi]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNESHLLSDYKDD

Download         Length: 171 bp

>AT240038 NZ_LS483476:735908-736189 [Lederbergia lentus]
GTGTCAGAATCCAGCGCAACAACAGAAATTATTATACGATTGCCGCAGCAACTTATCGCGGAAATGGATGGTTATGCAGA
GCAAGAAAATCTAAATCATAGCGAAATTATTTATCGTGCTACTAAGGTGTATCTTCGTGAGCGAAAAAAACGCCAAATCA
TTGAATCCATGAGACGCGGATATATGGAGATGGCCAAAATTAATTTGGCGATTGCATCAGAAGCTCTCCAAGCGGAATAT
GAGGCAGAAAACACAGTCGAACGGCTTGTAAGCGGAGGATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBS2X8B9


Antitoxin

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Source
ID
Structure
AlphaFold DBS2XCM0

References