Detailed information of TA system TA240036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 995897..996667
• Replicon: chromosome
• Accession: NZ_CP094712
• Organism: Staphylococcus schleiferi strain IVB6183

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA40_RS04635
• Protein ID: WP_016425469.1
• Coordinates: 996515..996667 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: S2Y062
• Locus tag: MUA40_RS04630
• Protein ID: WP_016425470.1
• Coordinates: 995897..996496 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA40_RS04610 (MUA40_04600)	991760..993220	+	1461	WP_126496414.1	ABC transporter permease subunit	-
MUA40_RS04615 (MUA40_04605)	993213..993941	+	729	WP_167733053.1	amino acid ABC transporter ATP-binding protein	-
MUA40_RS04620 (MUA40_04610)	994117..995247	+	1131	WP_262569947.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA40_RS04625 (MUA40_04615)	995247..995717	+	471	WP_016425471.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA40_RS04630 (MUA40_04620)	995897..996496	+	600	WP_016425470.1	hypothetical protein	Antitoxin
MUA40_RS04635 (MUA40_04625)	996515..996667	+	153	WP_016425469.1	SAS053 family protein	Toxin
MUA40_RS04640 (MUA40_04630)	996817..997242	+	426	WP_016425468.1	hypothetical protein	-
MUA40_RS04645 (MUA40_04635)	997414..998799	+	1386	WP_262569950.1	class II fumarate hydratase	-
MUA40_RS04650 (MUA40_04640)	998820..1000346	+	1527	WP_016425466.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-197)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5931.35 Da
• Isoelectric Point: 3.9615

>T240036 WP_016425469.1 NZ_CP094712:996515-996667 [Staphylococcus schleiferi]
MKDDQKQYENEMVEGFDDVVELGKEMEQISEKNDQDKLNQDHDADIRSDK

Nucleotide

• Length: 153 bp

>T240036 NZ_LS483473:462430-462714 [Pasteurella multocida]
GTGGGTCGGTTAAAGGAGGTAAAAATTTTATCCGCCAAATCTGCTGTTCTTGCTCGTATTAACAAAGCAATGAATGGTAA
TTTTGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22182.12 Da
• Isoelectric Point: 5.5527

>AT240036 WP_016425470.1 NZ_CP094712:995897-996496 [Staphylococcus schleiferi]
MAMNFKIFKDAETVAKYTADILRKQLNNNPTSIVGVHLNEDQAPVLNFLKQDVDRHSVDFSQIHILDYDKQASFFKSLGV
PEKQVHEVPDDDNVESFIAHHAKTKDNKGKLTLQVLTIDENGQIGLPMNDAVMPAREIIVVVTGSNKAAQVQKLYEENGN
TSFIPSTLKTHRMVTVVLDEAAAQGLPDDVRAYFTSLYA

Nucleotide

• Length: 600 bp

>AT240036 NZ_LS483473:462711-463004 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAAGTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTATGCATTCCTTAGGTATTAAACTTGTCCCAACGCACATCTAA

Structures

Antitoxin

• AlphaFold DB: S2Y062