Detailed information of TA system TA240033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 997440..998210
• Replicon: chromosome
• Accession: NZ_CP094711
• Organism: Staphylococcus schleiferi strain IVB6184

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA46_RS04630
• Protein ID: WP_016425469.1
• Coordinates: 998058..998210 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: S2Y062
• Locus tag: MUA46_RS04625
• Protein ID: WP_016425470.1
• Coordinates: 997440..998039 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA46_RS04605 (MUA46_04595)	993303..994763	+	1461	WP_126496414.1	ABC transporter permease subunit	-
MUA46_RS04610 (MUA46_04600)	994756..995484	+	729	WP_167733053.1	amino acid ABC transporter ATP-binding protein	-
MUA46_RS04615 (MUA46_04605)	995660..996790	+	1131	WP_262569947.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA46_RS04620 (MUA46_04610)	996790..997260	+	471	WP_016425471.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA46_RS04625 (MUA46_04615)	997440..998039	+	600	WP_016425470.1	hypothetical protein	Antitoxin
MUA46_RS04630 (MUA46_04620)	998058..998210	+	153	WP_016425469.1	SAS053 family protein	Toxin
MUA46_RS04635 (MUA46_04625)	998360..998785	+	426	WP_016425468.1	hypothetical protein	-
MUA46_RS04640 (MUA46_04630)	998957..1000342	+	1386	WP_126496425.1	class II fumarate hydratase	-
MUA46_RS04645 (MUA46_04635)	1000363..1001889	+	1527	WP_016425466.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-197)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5931.35 Da
• Isoelectric Point: 3.9615

>T240033 WP_016425469.1 NZ_CP094711:998058-998210 [Staphylococcus schleiferi]
MKDDQKQYENEMVEGFDDVVELGKEMEQISEKNDQDKLNQDHDADIRSDK

Nucleotide

• Length: 153 bp

>T240033 NZ_LS483471:760768-761133 [Streptococcus cristatus]
GTGCATAATATCTATTTTTACAAGGATAAGAACGGTAATGAGCCTGTTTTAGATTATATGCGAGAGCTTGCCAGTAAAAA
GGGAAAAGATAGTAGAATTAAACTCAATAAAATCAATGATTATATTGAGTTGTTAAGCCAGCATGGAACACGCGCAGGTG
AGCCATATATTAAGCATTTAGATGCTGAAATTTGGGAACTTAGACCACTAAGGGATAGGGTTTTATTTGTTGCTTGGATT
GATGGCAGTTTCGTTTTATTGCATCATTTTATGAAAAAGACACAGAAGACTCCAAAGAGAGAAATTGAACAAGCCAAGCG
TGAATTAGAAGATTTAAAAGAAAGAGGGCTAGATAATGAAAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22182.12 Da
• Isoelectric Point: 5.5527

>AT240033 WP_016425470.1 NZ_CP094711:997440-998039 [Staphylococcus schleiferi]
MAMNFKIFKDAETVAKYTADILRKQLNNNPTSIVGVHLNEDQAPVLNFLKQDVDRHSVDFSQIHILDYDKQASFFKSLGV
PEKQVHEVPDDDNVESFIAHHAKTKDNKGKLTLQVLTIDENGQIGLPMNDAVMPAREIIVVVTGSNKAAQVQKLYEENGN
TSFIPSTLKTHRMVTVVLDEAAAQGLPDDVRAYFTSLYA

Nucleotide

• Length: 600 bp

>AT240033 NZ_LS483471:761123-761416 [Streptococcus cristatus]
ATGAAAAATAGTGCGATCGGCAGCAATTGGAAAGATGTTAGAGCTGAGCTTTTTAGCAAAGAGGAGATTTTAGAAAGTGA
TATGCGCGTGGCTATCATGAGCGAGCTTATCGAGGCCAGAAATGAGAAGGGAATAAGCCAAAAGAAATTGGAGGAATTAA
GTGGTGTAAGTCAGCCTGTCATTGCTAGAATGGAAACAGGTAAGACAAGCCCGCAACTGGACACGGTGCTAAAAGTATTA
GCAAGTCTGGGAAAAACTTTAGCAGTGGTACCTTTAGAACATGAACAGGCATAG

Structures

Antitoxin

• AlphaFold DB: S2Y062