Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 976871..977385 Replicon chromosome
Accession NZ_CP094709
Organism Staphylococcus simulans strain IVB6174

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA82_RS04405 Protein ID WP_031262808.1
Coordinates 977035..977385 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4QNU3
Locus tag MUA82_RS04400 Protein ID WP_023016097.1
Coordinates 976871..977038 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA82_RS04375 (MUA82_04375) 972761..973225 + 465 WP_262583274.1 PH domain-containing protein -
MUA82_RS04380 (MUA82_04380) 973218..974711 + 1494 WP_107587564.1 PH domain-containing protein -
MUA82_RS04385 (MUA82_04385) 974704..975201 + 498 WP_107587565.1 PH domain-containing protein -
MUA82_RS04390 (MUA82_04390) 975203..975556 + 354 WP_070626517.1 holo-ACP synthase -
MUA82_RS04395 (MUA82_04395) 975636..976790 + 1155 WP_023016098.1 alanine racemase -
MUA82_RS04400 (MUA82_04400) 976871..977038 + 168 WP_023016097.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA82_RS04405 (MUA82_04405) 977035..977385 + 351 WP_031262808.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA82_RS04410 (MUA82_04410) 977677..978678 + 1002 WP_002481750.1 SpoIIE family protein phosphatase -
MUA82_RS04415 (MUA82_04415) 978754..979080 + 327 WP_002481749.1 anti-sigma factor antagonist -
MUA82_RS04420 (MUA82_04420) 979082..979561 + 480 WP_023016096.1 anti-sigma B factor RsbW -
MUA82_RS04425 (MUA82_04425) 979536..980306 + 771 WP_002481747.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.09 Da        Isoelectric Point: 10.0474

>T240031 WP_031262808.1 NZ_CP094709:977035-977385 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Download         Length: 351 bp

>T240031 NZ_LS483470:c3158764-3158495 [Leminorella richardii]
ATGTGGGTTGAATGGACTGATGACGCTCAGGAAGAGCTATGGGCAATTATCGATTACATTGACGATTACAATTCTCAAGC
GGCCTTTCAACTTTACAGAGATATTATTGCTGCTACAGAAGCTCTACTTTCTTACCCTTATAGACATCGCCAAGGAAGAG
TATTAAGCACGCGGGAAATTGTAGTTCATCCTAACTATATTGTTGTTTATCGAATTTCTGACCGCATTGAAATTCTTAGT
GTTCTACATGCAAAGCGGGAGTATCCCTGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6257.78 Da        Isoelectric Point: 3.6836

>AT240031 WP_023016097.1 NZ_CP094709:976871-977038 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Download         Length: 168 bp

>AT240031 NZ_LS483470:c3158945-3158754 [Leminorella richardii]
ATGACGATAAAGCCATCGCCTACCGAATCCGAGTTTGAGACTCAGGAACAGGCCAATAGTTACGATCGCTGGTTTAGGGC
TAAGGTTGAAGCCGCAATGAACAGCGCTAAGCCTCGGATCCCGCATGAGCAAGTTATTGCTGAAATACAGGTGCGTTTGG
ACGCAAAGCGAAAGGTACATAATGTGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4QNU3

References