Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1019224..1020656 Replicon chromosome
Accession NC_012926
Organism Streptococcus suis BM407

Toxin (Protein)


Gene name abiEi Uniprot ID A0A0H3MV40
Locus tag SSUBM407_RS04995 Protein ID WP_012775600.1
Coordinates 1019224..1020069 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A0H3MZG0
Locus tag SSUBM407_RS05000 Protein ID WP_012775601.1
Coordinates 1020066..1020656 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUBM407_RS04990 1016361..1019162 + 2802 WP_012775599.1 CHAP domain-containing protein -
SSUBM407_RS04995 1019224..1020069 - 846 WP_012775600.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
SSUBM407_RS05000 1020066..1020656 - 591 WP_012775601.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32444.16 Da        Isoelectric Point: 5.2246

>T24003 WP_012775600.1 NC_012926:c1020069-1019224 [Streptococcus suis BM407]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIFSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLIAVLISINSD

Download         Length: 846 bp

>T24003 NC_012926:c1020069-1019224 [Streptococcus suis BM407]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTAGAAGTGATTTTGAAAAAATTAAGTCAGAGTAGCTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATTGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATCACACTTTCAGAAGAT
ACTGTGAAGCAGCAACTCAAAGAAATTTTAGCAGATTCAGAAGAAGGTATATCTTTTGTGATTCAATCCATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTTGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGCGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGAAAATTTTCCA
ATCATTGCTTATACAATTGAAACAATCCTAGCTGAGAAACTTCAAACCATCTTTTCACGTAACTTCTTGAACAGCAGAAG
CAAAGATTTTTATGATGTTTATATTCTATCAAAACTAAAGAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAGCTCGATTTTGAAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCGAAAAAATATAGCTATACAAAGGGGATTTCCCTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAGCAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23189.70 Da        Isoelectric Point: 7.3108

>AT24003 WP_012775601.1 NC_012926:c1020656-1020066 [Streptococcus suis BM407]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRAYDFERIICDLVIHREKIDTELFVKT
LQHYGNYPQKNLTKLYEYATKMNTLAKVKQTLEVLV

Download         Length: 591 bp

>AT24003 NC_012926:c1020656-1020066 [Streptococcus suis BM407]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGTATTATCACCTATAAAGATTGTAAAGCTCTAAA
TATTCCAACAATCTATTTGACAAGACTAGAAAAAGAAGGAATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGATATCCAAAAGCTGTTTTCTCATATATCTCAGCGCTTTATCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGTTACCGTTTTAATACTCCTCCAGCTAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAATTAGGAATTACTCTTGTAAAAACCCCTATGGGAAACGAGGTAA
GAGCGTATGATTTCGAACGTATTATCTGTGATTTGGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATCCTCAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGCCAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3MV40

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3MZG0

References