Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 982770..983284 Replicon chromosome
Accession NZ_CP094707
Organism Staphylococcus simulans strain IVB6192

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA28_RS04410 Protein ID WP_031262808.1
Coordinates 982934..983284 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4QNU3
Locus tag MUA28_RS04405 Protein ID WP_023016097.1
Coordinates 982770..982937 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA28_RS04380 (MUA28_04370) 978660..979124 + 465 WP_070848604.1 PH domain-containing protein -
MUA28_RS04385 (MUA28_04375) 979117..980610 + 1494 WP_262571624.1 PH domain-containing protein -
MUA28_RS04390 (MUA28_04380) 980603..981100 + 498 WP_060804061.1 PH domain-containing protein -
MUA28_RS04395 (MUA28_04385) 981102..981455 + 354 WP_031262810.1 holo-ACP synthase -
MUA28_RS04400 (MUA28_04390) 981535..982689 + 1155 WP_070848601.1 alanine racemase -
MUA28_RS04405 (MUA28_04395) 982770..982937 + 168 WP_023016097.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA28_RS04410 (MUA28_04400) 982934..983284 + 351 WP_031262808.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA28_RS04415 (MUA28_04405) 983576..984577 + 1002 WP_002481750.1 SpoIIE family protein phosphatase -
MUA28_RS04420 (MUA28_04410) 984653..984979 + 327 WP_002481749.1 anti-sigma factor antagonist -
MUA28_RS04425 (MUA28_04415) 984981..985460 + 480 WP_023016096.1 anti-sigma B factor RsbW -
MUA28_RS04430 (MUA28_04420) 985435..986205 + 771 WP_002481747.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.09 Da        Isoelectric Point: 10.0474

>T240026 WP_031262808.1 NZ_CP094707:982934-983284 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Download         Length: 351 bp

>T240026 NZ_LS483470:1042298-1042585 [Leminorella richardii]
ATGAGTTATGCGGTCAAGTTTAGACGCGATGCATTGAAAGAGTGGCAAAAGCTGGATAAAGCCATTCAGCAGCAGTTTGC
TAAAAAGCTAAAGAAGTGCTGTGAAGAGCCTCATCTTCCTGCGGCTAGGCTAAGCGGCATGCCGGATTGCTATAAAATTA
AGCTTCGATCTTCTGGATTCCGCCTTGTTTATCAGGTTATTAATGACGAGCTGCTTGTTGTCGTCGTTGCAGTAGGCAAG
CGAGAGCGCAGCGGTGTTTATCATCTGGCTAGCGAGCGTATGAGATAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6257.78 Da        Isoelectric Point: 3.6836

>AT240026 WP_023016097.1 NZ_CP094707:982770-982937 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Download         Length: 168 bp

>AT240026 NZ_LS483470:1042050-1042301 [Leminorella richardii]
ATGCCAAATTTGATTTTAAGTGATATCAGCGCCAGCGTCAGTGAGTTAAAAAAGAACCCAATGGCAACGGTTAATGCAGG
AGCAGGATATCCAGTGGCAATTTTAAATCGTAACCAGCCCGCTTTTTACTGTGTCCCTGCGGAGCTGTATGAACAAATTT
TAGACGCGCTAGACGAGCATGAACTGGTGAAACTGGTCAAGGAGCGTCAGGGCCAGCCGCTGGTTGAGGTGGATTTGGAC
TCATATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4QNU3

References