Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 969472..969986 Replicon chromosome
Accession NZ_CP094707
Organism Staphylococcus simulans strain IVB6192

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag MUA28_RS04340 Protein ID WP_002481764.1
Coordinates 969780..969986 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag MUA28_RS04335 Protein ID WP_002481765.1
Coordinates 969472..969765 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA28_RS04310 (MUA28_04300) 964867..965505 + 639 WP_002481770.1 thiamine phosphate synthase -
MUA28_RS04315 (MUA28_04305) 965594..966463 + 870 WP_002481769.1 membrane protein insertase YidC -
MUA28_RS04320 (MUA28_04310) 966589..967101 + 513 WP_002481768.1 GNAT family N-acetyltransferase -
MUA28_RS04325 (MUA28_04315) 967158..967808 - 651 WP_262571613.1 HD domain-containing protein -
MUA28_RS04330 (MUA28_04320) 967832..969313 - 1482 WP_060804055.1 cardiolipin synthase -
MUA28_RS04335 (MUA28_04325) 969472..969765 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA28_RS04340 (MUA28_04330) 969780..969986 + 207 WP_002481764.1 heavy metal-associated domain-containing protein Toxin
MUA28_RS04345 (MUA28_04335) 970005..970211 + 207 WP_002481763.1 copper ion binding protein -
MUA28_RS04350 (MUA28_04340) 970304..972496 + 2193 WP_262571615.1 heavy metal translocating P-type ATPase -
MUA28_RS04355 (MUA28_04345) 972578..972718 + 141 WP_023016106.1 Lmo0850 family protein -
MUA28_RS04360 (MUA28_04350) 972778..973986 - 1209 WP_262571617.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T240025 WP_002481764.1 NZ_CP094707:969780-969986 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T240025 NZ_LS483470:c838157-837207 [Leminorella richardii]
ATGGATGACCTGAATGTTCTTTTTTCTGATGTCGCGGATGCGCTTGGCATAGAGTCCGTCGCTATTGTGGAAAAGGATCA
CTATATCGTTGAGCTCCTACGTTTACTCAAGCAGCTGACGTTTGACACTCACCAACTAGTATTCGCCGGAGGCACCGCAC
TGGCAAAATCCGGCGTTGCGCTCAACCGAATGTCAGAAGACGTAGATATTAAGCTGGTACCAACAGCGGCTTTTCAGGCG
CTTTCACGTAACCAGAGAAAAAATACCCGCAAAGCGATTGTCTTGGCAATCTCCGGCGCGATAACTACAACGGATGTGTT
TAGTTTTGATGACGACTACCCAAAAGTGACAAGGGATGAGTATTGCTATAGCGATATTCCGGTTCGTTACCCTCAGCGCG
TAGCACAGGCACCTTGCCTACGGCCTTTTATCCGGTTGGAACTGATGGAGTCAAACTTACTGGAGCCGCCGGAACCGCGG
GATATTCACTCCCTGATAACGGCATTAACGGGAAAAGCACCCGTTGTTTCAGCGTTTCCTTGCGCTACGGTTGCCAATAC
TCAGGCTGAAAAACTCGTGGCGATGCTGCGCCGAACGGCGGCAATAGTGCGAGATGTGGAACGATTTGACGACGCTTCTC
TGGTACGTCATATCTACGACACATACTGTATTGTTGAAGCGGGTGGCGTTAATATGCCCCTGCTTACTGATTATGTTCAG
CGAACCATCGAGCAGGACATTCAACGTTACGGCAGTCAATACCCGCAGTTTTGTACTTCTCCTATTGATGAACTGAAAAT
GGGATTGGATGAGCTGGCGTGTAATCCGCTCTATCAGACACGCTACCAGCAGTTTGTTGCTCCGATGGTGTATGGTGCAC
GTAAAGCCTCATGGGATGAAGCGTACGCCAGTTTCCGACAGATCGCGCTAGCCATTCTGAATGCTGACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT240025 WP_002481765.1 NZ_CP094707:969472-969765 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT240025 NZ_LS483470:c838545-838150 [Leminorella richardii]
ATGACGATAAAAGCACGCATTCAGTCACGACTGAAACGTTCAAAACGCTATGTATTCACTCGTGACGATTTCAAAGACAT
TGCAGGCTACGACCAGGTTGGCAGAGTGTTGCGCGATCTGATCAAAGAAGGGCAACTACTAAAAGTAGGATATGGCGTAT
ACACCAAAGCCCGCCAAAACAGCATCACCGGTAAAGTAATGCCTGCCGCGCCTGGAGGATCTTCAGCGGTGATCGTTGAA
ACGCTTGAGCGCCTGAAAGTACGCTATCGCCTTGCCGAAGAAACGCAAGCCTATAACAGCGGTAACTCCACGCAGATCCC
AGCATCACCAGAAATCAAAACCTCTTCGCGTTTTAAACGCGCACTGTCAGTAGGGAGCAGTAAACTCAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References