Detailed information of TA system TA240024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1004483..1004997
• Replicon: chromosome
• Accession: NZ_CP094706
• Organism: Staphylococcus simulans strain IVB6193

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MUA57_RS04485
• Protein ID: WP_031262808.1
• Coordinates: 1004647..1004997 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A2T4QNU3
• Locus tag: MUA57_RS04480
• Protein ID: WP_023016097.1
• Coordinates: 1004483..1004650 (+)
• Length: 56 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA57_RS04455 (MUA57_04455)	1000373..1000837	+	465	WP_105967036.1	PH domain-containing protein	-
MUA57_RS04460 (MUA57_04460)	1000830..1002323	+	1494	WP_107587564.1	PH domain-containing protein	-
MUA57_RS04465 (MUA57_04465)	1002316..1002813	+	498	WP_023016100.1	PH domain-containing protein	-
MUA57_RS04470 (MUA57_04470)	1002815..1003168	+	354	WP_031262810.1	holo-ACP synthase	-
MUA57_RS04475 (MUA57_04475)	1003248..1004402	+	1155	WP_105967038.1	alanine racemase	-
MUA57_RS04480 (MUA57_04480)	1004483..1004650	+	168	WP_023016097.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MUA57_RS04485 (MUA57_04485)	1004647..1004997	+	351	WP_031262808.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MUA57_RS04490 (MUA57_04490)	1005289..1006290	+	1002	WP_002481750.1	SpoIIE family protein phosphatase	-
MUA57_RS04495 (MUA57_04495)	1006366..1006692	+	327	WP_002481749.1	anti-sigma factor antagonist	-
MUA57_RS04500 (MUA57_04500)	1006694..1007173	+	480	WP_023016096.1	anti-sigma B factor RsbW	-
MUA57_RS04505 (MUA57_04505)	1007148..1007918	+	771	WP_002481747.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12976.09 Da
• Isoelectric Point: 10.0474

>T240024 WP_031262808.1 NZ_CP094706:1004647-1004997 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Nucleotide

• Length: 351 bp

>T240024 NZ_LS483468:426738-427322 [Rhodococcus coprophilus]
GTGAGGCGACTCGATCTCGTCGTCGGGCCCAACGGATCCGGAAAGTCCACGTTCGTCGAGCAGCGTCTCGCTCCCCTGCT
GCCCGGCAGTGTGTTCGTCAACGCCGATGTGATCGCCAAGCAGCGGTGGCCCGACAGCCCGGAGGAGCATTCCTACGAGG
CCGCGCAGATCGCCGCGACCATCCGTGACCTGCTGATCGACCAGGGCGAGTCGTTCATCGCCGAGACGGTGTTCTCGCAT
CCGTCGAAACTCGATCTGATCGACCGGGCGCAGCGCGCCGGGTACGTGGTGGTGCTGCATGTGGTGCTCGTGCCCGTGGA
GTTGTCGGTGGCCCGTGTTGCCGAACGCGTCGTGGAAGGCGGCCATCGCGTCCCCGAAGAGAAGATCCGCTCCCGCTTCG
ACCGGCTGTGGCCGCTGGTGGCGGACGCGATCGGGCGGGCCGACCACGCGACCGTCTACGACAACACCGCCGCGGACGTC
ACCCGGATCGCGGCGCGGTTCGTCGACGGTGATGCGGTCGGCGAGGTCGCGTGGCCCGCGTGGACGCCTGCGGCGTTGAC
CGGCGCACCGACCGTCTCGGGCTGA

Antitoxin

Protein

• Length: 56 a.a.
• Molecular weight: 6257.78 Da
• Isoelectric Point: 3.6836

>AT240024 WP_023016097.1 NZ_CP094706:1004483-1004650 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Nucleotide

• Length: 168 bp

>AT240024 NZ_LS483468:426364-426741 [Rhodococcus coprophilus]
ATGACGAACGTCGTCGACAAGGTGACCAGGTTCTCGTCCGAGCTCGTCGACGCGGCTGCGTCCGAAGGCGAACGGGAGAA
CCGTTCGGCCCGTCAGCAATTGGAACACTGGGCGCGTGTCGGCCGTGAGGTGTCCAACCAGCGTCAGGTCGCGAGGCGCC
GCGTCGAAGCCGCGCTCGCCGGGCGGCTGCCGCTGCGCGAACTTTCCGACGAAGAAGGCGTGGTGTTCAACGCCGAAATC
GCCGCCGCCCTCGAGGAATCCCTCGCCACCGGCCATCACGTCGACGACCGCGCCGCCCGCGGCCTGGCCTCGGTCGTGCT
CGACGAGCAGGGCCGCGTCGTCAAGCATCTGCCTGACGGCACCCAGATCGTGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2T4QNU3