Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 991185..991699 Replicon chromosome
Accession NZ_CP094706
Organism Staphylococcus simulans strain IVB6193

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag MUA57_RS04415 Protein ID WP_002481764.1
Coordinates 991493..991699 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag MUA57_RS04410 Protein ID WP_002481765.1
Coordinates 991185..991478 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA57_RS04390 (MUA57_04390) 986816..987328 + 513 WP_070848611.1 GNAT family N-acetyltransferase -
MUA57_RS04395 (MUA57_04395) 987450..988766 + 1317 WP_262549866.1 ISL3 family transposase -
MUA57_RS04400 (MUA57_04400) 988871..989521 - 651 WP_262549868.1 HD domain-containing protein -
MUA57_RS04405 (MUA57_04405) 989545..991026 - 1482 WP_023016108.1 cardiolipin synthase -
MUA57_RS04410 (MUA57_04410) 991185..991478 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA57_RS04415 (MUA57_04415) 991493..991699 + 207 WP_002481764.1 heavy metal-associated domain-containing protein Toxin
MUA57_RS04420 (MUA57_04420) 991718..991924 + 207 WP_002481763.1 copper ion binding protein -
MUA57_RS04425 (MUA57_04425) 992017..994209 + 2193 WP_262549870.1 heavy metal translocating P-type ATPase -
MUA57_RS04430 (MUA57_04430) 994291..994431 + 141 WP_023016106.1 Lmo0850 family protein -
MUA57_RS04435 (MUA57_04435) 994491..995699 - 1209 WP_002481760.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T240023 WP_002481764.1 NZ_CP094706:991493-991699 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T240023 NZ_LS483460:c1692700-1692419 [Corynebacterium minutissimum]
ATGATTCAGTCGTTTGCTAACCGAGACACCGAGCTTGTCTGGTTGCGCCAAGCGTCACCCCGGATCGATTCAAGAATTCA
CAAGACTGCAAATAGAAAACTTCATCAGCTTGATGCAGCAGTTTCCCTGCAATCGCTGCGTGTTCCGCCGGGGAACCGAT
TGGAAGCTTTGAAAGGTGATCGAAAGGGGATGTACAGCATTCGAGTCAATCAACAATGGAGGATTACTTTTCGCTGGACC
GAAGCGGGCCCGGCGGATGTGGCAATAGAGGATTATCACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT240023 WP_002481765.1 NZ_CP094706:991185-991478 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT240023 NZ_LS483460:c1692410-1692111 [Corynebacterium minutissimum]
ATGAGTACCAAGTTGTATCCACCTATTCATCCTGGAGAAGTACTCAACGAAGACTTCATTAAGGCATTTGGGATTACCCA
GCATAAGTTAGCTATGGCCATTGGAGTCCCTCCGCGCAGGATTAACGAGATCGTCCACGGCAAGCGCGGAATTACAGCAG
ACACTGCGCTGCGTTTAGGAAGGTATTTCGGGGTAGAACCGCAGTTCTGGGTGAACTTGCAAGGACGATACGAGCTCGAA
ATAGCAGAGGATTCAATCGCTGAAGAAGTCAGCAGTATTAAGCCGCTCGAAGTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References