Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1704620..1705439 Replicon chromosome
Accession NZ_CP094702
Organism Staphylococcus simulans strain IVB6209

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA41_RS08115 Protein ID WP_107547499.1
Coordinates 1704966..1705439 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA41_RS08110 Protein ID WP_105996454.1
Coordinates 1704620..1704952 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA41_RS08060 (MUA41_08050) 1699737..1700354 + 618 WP_262546167.1 hypothetical protein -
MUA41_RS08065 (MUA41_08055) 1700357..1700554 - 198 WP_262546169.1 hypothetical protein -
MUA41_RS08070 (MUA41_08060) 1700600..1700938 + 339 WP_058714326.1 hypothetical protein -
MUA41_RS08075 (MUA41_08065) 1700924..1701157 - 234 WP_030058915.1 DUF2829 domain-containing protein -
MUA41_RS08080 (MUA41_08070) 1701191..1701973 - 783 WP_262546171.1 Bro-N domain-containing protein -
MUA41_RS08085 (MUA41_08075) 1702085..1702447 + 363 WP_262546173.1 hypothetical protein -
MUA41_RS08090 (MUA41_08080) 1702703..1702930 - 228 WP_262546174.1 hypothetical protein -
MUA41_RS08095 (MUA41_08085) 1702942..1703715 - 774 WP_262546176.1 Rha family transcriptional regulator -
MUA41_RS08100 (MUA41_08090) 1703729..1704175 - 447 WP_262546178.1 hypothetical protein -
MUA41_RS08105 (MUA41_08095) 1704188..1704427 - 240 WP_262555573.1 helix-turn-helix transcriptional regulator -
MUA41_RS08110 (MUA41_08100) 1704620..1704952 + 333 WP_105996454.1 helix-turn-helix transcriptional regulator Antitoxin
MUA41_RS08115 (MUA41_08105) 1704966..1705439 + 474 WP_107547499.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA41_RS08120 (MUA41_08110) 1705444..1706067 + 624 WP_241963963.1 DUF4352 domain-containing protein -
MUA41_RS08125 (MUA41_08115) 1706477..1707130 + 654 WP_262546185.1 CPBP family intramembrane metalloprotease -
MUA41_RS08130 (MUA41_08120) 1707198..1708226 + 1029 WP_262546188.1 site-specific integrase -
MUA41_RS08135 (MUA41_08125) 1708238..1708417 - 180 WP_002480758.1 RNA chaperone Hfq -
MUA41_RS08140 (MUA41_08130) 1708414..1709376 - 963 WP_070864178.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
MUA41_RS08145 (MUA41_08135) 1709378..1710313 - 936 WP_262555577.1 lysophospholipase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1672098..1828835 156737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18524.69 Da        Isoelectric Point: 6.1428

>T240017 WP_107547499.1 NZ_CP094702:1704966-1705439 [Staphylococcus simulans]
MGVYEDLCIANDWVEIEETDRLPSFQPGFYRNGKIYIKSSLSETRKAEVLYEELAHHKLTYGNILDESSFNNRKFENYAR
RHGYENSISLNKIIDAYKYGVSSLHEFAEYVQLSEEYVHTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYKNLNEGD

Download         Length: 474 bp

>T240017 NZ_LS483452:345339-345734 [Shewanella benthica]
GTGACTAGAGTATTCAAAGCAAGGCCAATATTAGATGCACTAACTGAAGCAGAGCAACATCAGTTAGTAAGTGATTTTAA
GTCATACAAAGAGGGAGAGCTACCAGAACTTTTCGGTCGAGATGTTTTGTATGACCACCCAATGAACCTTGCAGCGATTA
AGGATGAAGAGGTTAGGCATCTACATTTGGGTAATGCTGATGCACCTTGGCCAATATGGAAAGCACAGTTCAATAGGACT
AGTGACAAACACTTAGTTTATTGCTGTGGTGATACTCACCCAGACAGATATTTGTTAATGGCTATCTTGACGCCTAGCGC
ACACGACAAGGCAAAAGATAACAATGTAATGAGTAGGCTGGGAACCATGGCTGAAAAGTTCAAAGAGATACATTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12869.51 Da        Isoelectric Point: 4.7176

>AT240017 WP_105996454.1 NZ_CP094702:1704620-1704952 [Staphylococcus simulans]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFTESEQKEQEQDT
MAAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Download         Length: 333 bp

>AT240017 NZ_LS483452:345049-345342 [Shewanella benthica]
ATGACTGTTCGTCTGATTTATGCTGAAAAAATAGTTTCAGCCACTGAGGTTAGAAAAGGTGTAAACCAGTATTTCATTGA
TGAGCCCGTTGCTGTTTTGTCTAACAACAAGCCGACAGGCTATATGGTAGGCGCAGCCTTATTTGAAAGGATGATTCTTT
TGATCGAAAAGCAATCTGAAGGTGCAAACTCTTCCTTTAGACCTGCTACCGCAAGGCTTCAGGCTATGGCTTTTGTTAGT
GAGAAGTCTTTGTTGAATGCTACTGATGATGAGCTAGGTGAATTTAGCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References