Detailed information of TA system TA240016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1026763..1027277
• Replicon: chromosome
• Accession: NZ_CP094702
• Organism: Staphylococcus simulans strain IVB6209

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MUA41_RS04630
• Protein ID: WP_031262808.1
• Coordinates: 1026927..1027277 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A2T4QNU3
• Locus tag: MUA41_RS04625
• Protein ID: WP_023016097.1
• Coordinates: 1026763..1026930 (+)
• Length: 56 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA41_RS04600 (MUA41_04595)	1022653..1023117	+	465	WP_060804059.1	PH domain-containing protein	-
MUA41_RS04605 (MUA41_04600)	1023110..1024603	+	1494	WP_262547355.1	PH domain-containing protein	-
MUA41_RS04610 (MUA41_04605)	1024596..1025093	+	498	WP_083326919.1	PH domain-containing protein	-
MUA41_RS04615 (MUA41_04610)	1025095..1025448	+	354	WP_070864323.1	holo-ACP synthase	-
MUA41_RS04620 (MUA41_04615)	1025528..1026682	+	1155	WP_070848601.1	alanine racemase	-
MUA41_RS04625 (MUA41_04620)	1026763..1026930	+	168	WP_023016097.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MUA41_RS04630 (MUA41_04625)	1026927..1027277	+	351	WP_031262808.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MUA41_RS04635 (MUA41_04630)	1027569..1028570	+	1002	WP_002481750.1	SpoIIE family protein phosphatase	-
MUA41_RS04640 (MUA41_04635)	1028646..1028972	+	327	WP_262556366.1	anti-sigma factor antagonist	-
MUA41_RS04645 (MUA41_04640)	1028974..1029453	+	480	WP_023016096.1	anti-sigma B factor RsbW	-
MUA41_RS04650 (MUA41_04645)	1029428..1030198	+	771	WP_002481747.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12976.09 Da
• Isoelectric Point: 10.0474

>T240016 WP_031262808.1 NZ_CP094702:1026927-1027277 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Nucleotide

• Length: 351 bp

>T240016 NZ_LS483451:c1708407-1708228 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGTTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 56 a.a.
• Molecular weight: 6257.78 Da
• Isoelectric Point: 3.6836

>AT240016 WP_023016097.1 NZ_CP094702:1026763-1026930 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Nucleotide

• Length: 168 bp

>AT240016 NZ_LS483451:c1708191-1707739 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• AlphaFold DB: A0A2T4QNU3