Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1013465..1013979 Replicon chromosome
Accession NZ_CP094702
Organism Staphylococcus simulans strain IVB6209

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag MUA41_RS04560 Protein ID WP_002481764.1
Coordinates 1013773..1013979 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag MUA41_RS04555 Protein ID WP_002481765.1
Coordinates 1013465..1013758 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA41_RS04530 (MUA41_04525) 1008860..1009498 + 639 WP_060804053.1 thiamine phosphate synthase -
MUA41_RS04535 (MUA41_04530) 1009587..1010456 + 870 WP_002481769.1 membrane protein insertase YidC -
MUA41_RS04540 (MUA41_04535) 1010582..1011094 + 513 WP_002481768.1 GNAT family N-acetyltransferase -
MUA41_RS04545 (MUA41_04540) 1011151..1011801 - 651 WP_262556360.1 HD domain-containing protein -
MUA41_RS04550 (MUA41_04545) 1011825..1013306 - 1482 WP_262556361.1 cardiolipin synthase -
MUA41_RS04555 (MUA41_04550) 1013465..1013758 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA41_RS04560 (MUA41_04555) 1013773..1013979 + 207 WP_002481764.1 heavy metal-associated domain-containing protein Toxin
MUA41_RS04565 (MUA41_04560) 1013998..1014204 + 207 WP_002481763.1 copper ion binding protein -
MUA41_RS04570 (MUA41_04565) 1014297..1016489 + 2193 WP_262556362.1 heavy metal translocating P-type ATPase -
MUA41_RS04575 (MUA41_04570) 1016571..1016711 + 141 WP_023016106.1 Lmo0850 family protein -
MUA41_RS04580 (MUA41_04575) 1016771..1017979 - 1209 WP_002481760.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T240015 WP_002481764.1 NZ_CP094702:1013773-1013979 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T240015 NZ_LS483451:c1652180-1651926 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGATTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCTTTC
AAAGATCATTACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT240015 WP_002481765.1 NZ_CP094702:1013465-1013758 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT240015 NZ_LS483451:c1652438-1652184 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References