240014

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 2284578..2285396 Replicon chromosome
Accession NZ_CP094698
Organism Staphylococcus simulans strain IVB6241

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA31_RS10965 Protein ID WP_107540066.1
Coordinates 2284923..2285396 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA31_RS10960 Protein ID WP_105988752.1
Coordinates 2284578..2284910 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA31_RS10905 (MUA31_10905) 2280644..2280910 - 267 WP_262546608.1 DUF1108 family protein -
MUA31_RS10910 (MUA31_10910) 2281007..2281222 - 216 WP_106421056.1 hypothetical protein -
MUA31_RS10915 (MUA31_10915) 2281238..2281456 - 219 WP_105988757.1 hypothetical protein -
MUA31_RS10920 (MUA31_10920) 2281511..2281738 + 228 WP_023015315.1 hypothetical protein -
MUA31_RS10925 (MUA31_10925) 2281760..2281897 - 138 WP_158257375.1 hypothetical protein -
MUA31_RS10930 (MUA31_10930) 2282161..2282424 - 264 WP_105988756.1 hypothetical protein -
MUA31_RS10935 (MUA31_10935) 2282505..2282871 + 367 Protein_2126 hypothetical protein -
MUA31_RS10940 (MUA31_10940) 2282840..2283085 - 246 WP_070684231.1 DUF2829 domain-containing protein -
MUA31_RS10945 (MUA31_10945) 2283135..2283362 - 228 WP_105988755.1 hypothetical protein -
MUA31_RS10950 (MUA31_10950) 2283363..2284130 - 768 Protein_2129 phage antirepressor KilAC domain-containing protein -
MUA31_RS10955 (MUA31_10955) 2284127..2284381 - 255 WP_262546611.1 helix-turn-helix transcriptional regulator -
MUA31_RS10960 (MUA31_10960) 2284578..2284910 + 333 WP_105988752.1 helix-turn-helix transcriptional regulator Antitoxin
MUA31_RS10965 (MUA31_10965) 2284923..2285396 + 474 WP_107540066.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA31_RS10970 (MUA31_10970) 2285401..2285958 + 558 WP_234016559.1 Ltp family lipoprotein -
MUA31_RS10975 (MUA31_10975) 2286136..2286288 + 153 WP_158257374.1 hypothetical protein -
MUA31_RS10980 (MUA31_10980) 2286372..2286560 + 189 WP_105988749.1 hypothetical protein -
MUA31_RS10985 (MUA31_10985) 2286625..2286858 + 234 WP_105988748.1 hypothetical protein -
MUA31_RS10990 (MUA31_10990) 2287089..2287325 + 237 WP_057510972.1 hypothetical protein -
MUA31_RS10995 (MUA31_10995) 2287346..2288122 + 777 WP_107534192.1 DUF1828 domain-containing protein -
MUA31_RS11000 (MUA31_11000) 2288189..2289238 + 1050 WP_262546614.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2244375..2310729 66354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18538.76 Da        Isoelectric Point: 6.3804

>T240014 WP_107540066.1 NZ_CP094698:2284923-2285396 [Staphylococcus simulans]
MGVYEDLCIANDWVEIEETDRLPSFQPGFYRNGKIYIKSSLSETRKAEVLYEELAHHKLTYGNILDESSFNNRKFENYAR
RHGYENSISLNKIIDAYKYGVSSLHEFAEYVQLSEEYVHTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYKKLNEGD

Download         Length: 474 bp

>T240014 NZ_LS483451:c1169404-1169150 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGAAAGCCCCAAGACAACACGGAAAGGCTTTGGTTGGTAATCGTGTTGGTCAATGGCGCT
ATAGAATTGGCAATTATCGAGTTATTGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12924.59 Da        Isoelectric Point: 4.8625

>AT240014 WP_105988752.1 NZ_CP094698:2284578-2284910 [Staphylococcus simulans]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFKESEQKEQEQDT
MAAHFDKEGLTEEEIEEVNRFIEWVKNRDK

Download         Length: 333 bp

>AT240014 NZ_LS483451:c1169648-1169406 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References