240010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1685273..1686092 Replicon chromosome
Accession NZ_CP094698
Organism Staphylococcus simulans strain IVB6241

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA31_RS08020 Protein ID WP_107547499.1
Coordinates 1685619..1686092 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA31_RS08015 Protein ID WP_105996454.1
Coordinates 1685273..1685605 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA31_RS07965 (MUA31_07965) 1680390..1681007 + 618 WP_262546167.1 hypothetical protein -
MUA31_RS07970 (MUA31_07970) 1681010..1681207 - 198 WP_262546169.1 hypothetical protein -
MUA31_RS07975 (MUA31_07975) 1681253..1681591 + 339 WP_058714326.1 hypothetical protein -
MUA31_RS07980 (MUA31_07980) 1681577..1681810 - 234 WP_030058915.1 DUF2829 domain-containing protein -
MUA31_RS07985 (MUA31_07985) 1681844..1682626 - 783 WP_262546171.1 Bro-N domain-containing protein -
MUA31_RS07990 (MUA31_07990) 1682738..1683100 + 363 WP_262546173.1 hypothetical protein -
MUA31_RS07995 (MUA31_07995) 1683356..1683583 - 228 WP_262546174.1 hypothetical protein -
MUA31_RS08000 (MUA31_08000) 1683595..1684368 - 774 WP_262546176.1 Rha family transcriptional regulator -
MUA31_RS08005 (MUA31_08005) 1684382..1684828 - 447 WP_262546178.1 hypothetical protein -
MUA31_RS08010 (MUA31_08010) 1684841..1685080 - 240 WP_262546181.1 helix-turn-helix transcriptional regulator -
MUA31_RS08015 (MUA31_08015) 1685273..1685605 + 333 WP_105996454.1 helix-turn-helix transcriptional regulator Antitoxin
MUA31_RS08020 (MUA31_08020) 1685619..1686092 + 474 WP_107547499.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA31_RS08025 (MUA31_08025) 1686097..1686720 + 624 WP_241963963.1 DUF4352 domain-containing protein -
MUA31_RS08030 (MUA31_08030) 1687131..1687784 + 654 WP_262546185.1 CPBP family intramembrane metalloprotease -
MUA31_RS08035 (MUA31_08035) 1687852..1688880 + 1029 WP_262546188.1 site-specific integrase -
MUA31_RS08040 (MUA31_08040) 1688892..1689071 - 180 WP_002480758.1 RNA chaperone Hfq -
MUA31_RS08045 (MUA31_08045) 1689068..1690030 - 963 WP_070848269.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
MUA31_RS08050 (MUA31_08050) 1690032..1690967 - 936 WP_070848268.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1644605..1688880 44275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18524.69 Da        Isoelectric Point: 6.1428

>T240010 WP_107547499.1 NZ_CP094698:1685619-1686092 [Staphylococcus simulans]
MGVYEDLCIANDWVEIEETDRLPSFQPGFYRNGKIYIKSSLSETRKAEVLYEELAHHKLTYGNILDESSFNNRKFENYAR
RHGYENSISLNKIIDAYKYGVSSLHEFAEYVQLSEEYVHTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYKNLNEGD

Download         Length: 474 bp

>T240010 NZ_LS483450:c1211992-1211738 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12869.51 Da        Isoelectric Point: 4.7176

>AT240010 WP_105996454.1 NZ_CP094698:1685273-1685605 [Staphylococcus simulans]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFTESEQKEQEQDT
MAAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Download         Length: 333 bp

>AT240010 NZ_LS483450:c1212236-1211994 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References