Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1002444..1002958 Replicon chromosome
Accession NZ_CP094698
Organism Staphylococcus simulans strain IVB6241

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA31_RS04520 Protein ID WP_031262808.1
Coordinates 1002608..1002958 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4QNU3
Locus tag MUA31_RS04515 Protein ID WP_023016097.1
Coordinates 1002444..1002611 (+) Length 56 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA31_RS04490 (MUA31_04495) 998334..998798 + 465 WP_060804059.1 PH domain-containing protein -
MUA31_RS04495 (MUA31_04500) 998791..1000284 + 1494 WP_262547355.1 PH domain-containing protein -
MUA31_RS04500 (MUA31_04505) 1000277..1000774 + 498 WP_083326919.1 PH domain-containing protein -
MUA31_RS04505 (MUA31_04510) 1000776..1001129 + 354 WP_070864323.1 holo-ACP synthase -
MUA31_RS04510 (MUA31_04515) 1001209..1002363 + 1155 WP_070848601.1 alanine racemase -
MUA31_RS04515 (MUA31_04520) 1002444..1002611 + 168 WP_023016097.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA31_RS04520 (MUA31_04525) 1002608..1002958 + 351 WP_031262808.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA31_RS04525 (MUA31_04530) 1003250..1004251 + 1002 WP_002481750.1 SpoIIE family protein phosphatase -
MUA31_RS04530 (MUA31_04535) 1004327..1004653 + 327 WP_002481749.1 anti-sigma factor antagonist -
MUA31_RS04535 (MUA31_04540) 1004655..1005134 + 480 WP_023016096.1 anti-sigma B factor RsbW -
MUA31_RS04540 (MUA31_04545) 1005109..1005879 + 771 WP_002481747.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-109)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.09 Da        Isoelectric Point: 10.0474

>T240009 WP_031262808.1 NZ_CP094698:1002608-1002958 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Download         Length: 351 bp

>T240009 NZ_LS483450:c1078109-1077351 [Streptococcus pneumoniae]
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTCGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGAGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTTCAGCAA
GAATATGGCAAAGACAGTGTTGAATACACCAAATATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAAGAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
GGGGATATGAAATACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATTAACCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAGGTTGTGTATATGATGCAA
AAGAAAATACAACTTCAGCGGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAAGTAGAGAAGGATATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6257.78 Da        Isoelectric Point: 3.6836

>AT240009 WP_023016097.1 NZ_CP094698:1002444-1002611 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Download         Length: 168 bp

>AT240009 NZ_LS483450:c1078585-1078109 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGAATTAACACAACCCGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGACTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTTTTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2T4QNU3

References