Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 998578..999092 | Replicon | chromosome |
| Accession | NZ_CP094697 | ||
| Organism | Staphylococcus simulans strain IVB6244 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | MUA81_RS04615 | Protein ID | WP_031262808.1 |
| Coordinates | 998742..999092 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | A0A2T4QNU3 |
| Locus tag | MUA81_RS04610 | Protein ID | WP_023016097.1 |
| Coordinates | 998578..998745 (+) | Length | 56 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA81_RS04585 (MUA81_04580) | 994468..994932 | + | 465 | WP_262901214.1 | PH domain-containing protein | - |
| MUA81_RS04590 (MUA81_04585) | 994925..996418 | + | 1494 | WP_107547572.1 | PH domain-containing protein | - |
| MUA81_RS04595 (MUA81_04590) | 996411..996908 | + | 498 | WP_262901215.1 | PH domain-containing protein | - |
| MUA81_RS04600 (MUA81_04595) | 996910..997263 | + | 354 | WP_031262810.1 | holo-ACP synthase | - |
| MUA81_RS04605 (MUA81_04600) | 997343..998497 | + | 1155 | WP_262901216.1 | alanine racemase | - |
| MUA81_RS04610 (MUA81_04605) | 998578..998745 | + | 168 | WP_023016097.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
| MUA81_RS04615 (MUA81_04610) | 998742..999092 | + | 351 | WP_031262808.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MUA81_RS04620 (MUA81_04615) | 999384..1000385 | + | 1002 | WP_262901217.1 | PP2C family protein-serine/threonine phosphatase | - |
| MUA81_RS04625 (MUA81_04620) | 1000461..1000787 | + | 327 | WP_002481749.1 | anti-sigma factor antagonist | - |
| MUA81_RS04630 (MUA81_04625) | 1000789..1001268 | + | 480 | WP_262901218.1 | anti-sigma B factor RsbW | - |
| MUA81_RS04635 (MUA81_04630) | 1001243..1002013 | + | 771 | WP_262901219.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12976.09 Da Isoelectric Point: 10.0474
>T240007 WP_031262808.1 NZ_CP094697:998742-999092 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN
Download Length: 351 bp
>T240007 NZ_LS483450:c953473-952703 [Streptococcus pneumoniae]
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTCGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAACCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTATACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTAATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAG
GAGAAGATAAAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTGTTAG
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTCGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAACCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTATACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTAATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAG
GAGAAGATAAAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATCGAAATGGTTGTTAG
Antitoxin
Download Length: 56 a.a. Molecular weight: 6257.78 Da Isoelectric Point: 3.6836
>AT240007 WP_023016097.1 NZ_CP094697:998578-998745 [Staphylococcus simulans]
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE
MSTFNQNRSYSLEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE
Download Length: 168 bp
>AT240007 NZ_LS483450:c953949-953473 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGAATTAACACAACCCGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGACTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTTTTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGAATTAACACAACCCGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGACTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTTTTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|