Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 985280..985794 Replicon chromosome
Accession NZ_CP094697
Organism Staphylococcus simulans strain IVB6244

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag MUA81_RS04545 Protein ID WP_002481764.1
Coordinates 985588..985794 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag MUA81_RS04540 Protein ID WP_002481765.1
Coordinates 985280..985573 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA81_RS04515 (MUA81_04510) 980674..981312 + 639 WP_107547577.1 thiamine phosphate synthase -
MUA81_RS04520 (MUA81_04515) 981401..982270 + 870 WP_002481769.1 membrane protein insertase YidC -
MUA81_RS04525 (MUA81_04520) 982396..982908 + 513 WP_070848611.1 GNAT family N-acetyltransferase -
MUA81_RS04530 (MUA81_04525) 982966..983616 - 651 WP_262901207.1 HD domain-containing protein -
MUA81_RS04535 (MUA81_04530) 983640..985121 - 1482 WP_262901208.1 cardiolipin synthase -
MUA81_RS04540 (MUA81_04535) 985280..985573 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA81_RS04545 (MUA81_04540) 985588..985794 + 207 WP_002481764.1 heavy metal-associated domain-containing protein Toxin
MUA81_RS04550 (MUA81_04545) 985813..986019 + 207 WP_002481763.1 copper ion binding protein -
MUA81_RS04555 (MUA81_04550) 986112..988304 + 2193 WP_262901209.1 heavy metal translocating P-type ATPase -
MUA81_RS04560 (MUA81_04555) 988386..988526 + 141 WP_023016106.1 Lmo0850 family protein -
MUA81_RS04565 (MUA81_04560) 988586..989794 - 1209 WP_262901210.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T240006 WP_002481764.1 NZ_CP094697:985588-985794 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T240006 NZ_LS483449:c1646349-1646170 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT240006 WP_002481765.1 NZ_CP094697:985280-985573 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT240006 NZ_LS483449:c1646133-1645681 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAGTGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References