Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1697766..1698585 Replicon chromosome
Accession NZ_CP094696
Organism Staphylococcus simulans strain IVB6251

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA73_RS08210 Protein ID WP_107547499.1
Coordinates 1698112..1698585 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA73_RS08205 Protein ID WP_105996454.1
Coordinates 1697766..1698098 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA73_RS08150 (MUA73_08140) 1693301..1693786 - 486 WP_107603985.1 siphovirus Gp157 family protein -
MUA73_RS08155 (MUA73_08145) 1693789..1694055 - 267 WP_060803545.1 DUF1108 family protein -
MUA73_RS08160 (MUA73_08150) 1694152..1694364 - 213 WP_262556893.1 hypothetical protein -
MUA73_RS08165 (MUA73_08155) 1694377..1694679 - 303 WP_002480770.1 DUF771 domain-containing protein -
MUA73_RS08170 (MUA73_08160) 1694729..1695226 + 498 WP_107588233.1 hypothetical protein -
MUA73_RS08175 (MUA73_08165) 1695344..1695667 + 324 WP_262556896.1 hypothetical protein -
MUA73_RS08180 (MUA73_08170) 1695656..1695814 - 159 WP_159079669.1 hypothetical protein -
MUA73_RS08185 (MUA73_08175) 1695861..1696076 - 216 WP_262556898.1 pathogenicity island protein -
MUA73_RS08190 (MUA73_08180) 1696088..1696861 - 774 WP_262556900.1 Rha family transcriptional regulator -
MUA73_RS08195 (MUA73_08185) 1696875..1697321 - 447 WP_107547498.1 hypothetical protein -
MUA73_RS08200 (MUA73_08190) 1697334..1697573 - 240 WP_262556903.1 helix-turn-helix transcriptional regulator -
MUA73_RS08205 (MUA73_08195) 1697766..1698098 + 333 WP_105996454.1 helix-turn-helix transcriptional regulator Antitoxin
MUA73_RS08210 (MUA73_08200) 1698112..1698585 + 474 WP_107547499.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA73_RS08215 (MUA73_08205) 1698590..1699213 + 624 WP_241963963.1 DUF4352 domain-containing protein -
MUA73_RS08220 (MUA73_08210) 1699614..1700267 + 654 WP_262546185.1 CPBP family intramembrane metalloprotease -
MUA73_RS08225 (MUA73_08215) 1700336..1701364 + 1029 WP_262556905.1 site-specific integrase -
MUA73_RS08230 (MUA73_08220) 1701376..1701555 - 180 WP_002480758.1 RNA chaperone Hfq -
MUA73_RS08235 (MUA73_08225) 1701552..1702514 - 963 WP_262556908.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
MUA73_RS08240 (MUA73_08230) 1702516..1703451 - 936 WP_262556910.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1662409..1701364 38955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18524.69 Da        Isoelectric Point: 6.1428

>T240005 WP_107547499.1 NZ_CP094696:1698112-1698585 [Staphylococcus simulans]
MGVYEDLCIANDWVEIEETDRLPSFQPGFYRNGKIYIKSSLSETRKAEVLYEELAHHKLTYGNILDESSFNNRKFENYAR
RHGYENSISLNKIIDAYKYGVSSLHEFAEYVQLSEEYVHTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYKNLNEGD

Download         Length: 474 bp

>T240005 NZ_LS483449:c1162483-1162229 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12869.51 Da        Isoelectric Point: 4.7176

>AT240005 WP_105996454.1 NZ_CP094696:1697766-1698098 [Staphylococcus simulans]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFTESEQKEQEQDT
MAAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Download         Length: 333 bp

>AT240005 NZ_LS483449:c1162727-1162485 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References