Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1012847..1013361 Replicon chromosome
Accession NZ_CP094696
Organism Staphylococcus simulans strain IVB6251

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag MUA73_RS04610 Protein ID WP_002481764.1
Coordinates 1013155..1013361 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag MUA73_RS04605 Protein ID WP_002481765.1
Coordinates 1012847..1013140 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA73_RS04580 (MUA73_04575) 1008242..1008880 + 639 WP_262557862.1 thiamine phosphate synthase -
MUA73_RS04585 (MUA73_04580) 1008969..1009838 + 870 WP_262557864.1 membrane protein insertase YidC -
MUA73_RS04590 (MUA73_04585) 1009964..1010476 + 513 WP_002481768.1 GNAT family N-acetyltransferase -
MUA73_RS04595 (MUA73_04590) 1010533..1011183 - 651 WP_262557865.1 HD domain-containing protein -
MUA73_RS04600 (MUA73_04595) 1011207..1012688 - 1482 WP_023016108.1 cardiolipin synthase -
MUA73_RS04605 (MUA73_04600) 1012847..1013140 + 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA73_RS04610 (MUA73_04605) 1013155..1013361 + 207 WP_002481764.1 heavy metal-associated domain-containing protein Toxin
MUA73_RS04615 (MUA73_04610) 1013380..1013586 + 207 WP_002481763.1 copper ion binding protein -
MUA73_RS04620 (MUA73_04615) 1013679..1015871 + 2193 WP_262557867.1 heavy metal translocating P-type ATPase -
MUA73_RS04625 (MUA73_04620) 1015953..1016093 + 141 WP_023016106.1 Lmo0850 family protein -
MUA73_RS04630 (MUA73_04625) 1016153..1017361 - 1209 WP_002481760.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T240003 WP_002481764.1 NZ_CP094696:1013155-1013361 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T240003 NZ_LS483448:c1673997-1673824 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATGGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT240003 WP_002481765.1 NZ_CP094696:1012847-1013140 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT240003 NZ_LS483448:c1673787-1673335 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References