Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 91959..92875 Replicon plasmid pTJPa150
Accession NZ_CP094678
Organism Pseudomonas aeruginosa strain Pa150

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag MTX71_RS31160 Protein ID WP_019437783.1
Coordinates 92351..92875 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag MTX71_RS31155 Protein ID WP_019437782.1
Coordinates 91959..92354 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX71_RS31140 (MTX71_31080) 87620..88144 - 525 WP_010794447.1 hypothetical protein -
MTX71_RS31145 (MTX71_31085) 89038..89292 - 255 WP_021263738.1 hypothetical protein -
MTX71_RS31150 (MTX71_31090) 89492..91375 + 1884 WP_223819158.1 helicase -
MTX71_RS31155 (MTX71_31095) 91959..92354 + 396 WP_019437782.1 hypothetical protein Antitoxin
MTX71_RS31160 (MTX71_31100) 92351..92875 + 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
MTX71_RS31165 (MTX71_31105) 92921..94171 - 1251 WP_019437784.1 TerD family protein -
MTX71_RS31170 (MTX71_31110) 94368..95423 - 1056 WP_109392701.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
MTX71_RS31175 (MTX71_31115) 95798..95989 + 192 WP_019437785.1 hypothetical protein -
MTX71_RS31180 (MTX71_31120) 96409..97554 - 1146 WP_021263240.1 glycerate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-IIa / cmlA1 / blaOXA-246 / qacE / sul1 / aac(3)-IId / rmtB / blaTEM-1B / aph(3'')-Ib / aph(6)-Id - 1..436716 436716


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T240002 WP_019437783.1 NZ_CP094678:92351-92875 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T240002 NZ_LS483448:c1623255-1623001 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT240002 WP_019437782.1 NZ_CP094678:91959-92354 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT240002 NZ_LS483448:c1623513-1623259 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References