Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 6003532..6004753 Replicon chromosome
Accession NZ_CP094677
Organism Pseudomonas aeruginosa strain Pa150

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX71_RS28135 Protein ID WP_003114949.1
Coordinates 6003532..6004110 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX71_RS28140 Protein ID WP_003088112.1
Coordinates 6004199..6004753 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX71_RS28120 (MTX71_28075) 5998809..6000086 + 1278 WP_003102743.1 TolC family protein -
MTX71_RS28125 (MTX71_28080) 6000076..6002247 + 2172 WP_042930112.1 type I secretion system permease/ATPase -
MTX71_RS28130 (MTX71_28085) 6002237..6003424 + 1188 WP_051488647.1 HlyD family efflux transporter periplasmic adaptor subunit -
MTX71_RS28135 (MTX71_28090) 6003532..6004110 - 579 WP_003114949.1 HD domain-containing protein Toxin
MTX71_RS28140 (MTX71_28095) 6004199..6004753 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
MTX71_RS28145 (MTX71_28100) 6004911..6007106 - 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MTX71_RS28150 (MTX71_28105) 6007111..6007572 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
MTX71_RS28155 (MTX71_28110) 6007903..6008226 + 324 WP_003102734.1 multidrug efflux SMR transporter -
MTX71_RS28160 (MTX71_28115) 6008239..6008637 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
MTX71_RS28165 (MTX71_28120) 6008634..6009185 - 552 WP_034038472.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T240001 WP_003114949.1 NZ_CP094677:c6004110-6003532 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T240001 NZ_LS483448:c1146378-1146124 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT240001 WP_003088112.1 NZ_CP094677:c6004753-6004199 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT240001 NZ_LS483448:c1146622-1146380 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References