Detailed information of TA system TA239998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2923543..2924048
• Replicon: chromosome
• Accession: NZ_CP094677
• Organism: Pseudomonas aeruginosa strain Pa150

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MTX71_RS13850
• Protein ID: WP_003083773.1
• Coordinates: 2923767..2924048 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MTX71_RS13845
• Protein ID: WP_003083775.1
• Coordinates: 2923543..2923770 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX71_RS13820 (MTX71_13790)	2918561..2920054	+	1494	WP_058169345.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
MTX71_RS13825 (MTX71_13795)	2920223..2921650	+	1428	WP_003083784.1	GABA permease	-
MTX71_RS13830 (MTX71_13800)	2921732..2922073	-	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MTX71_RS13835 (MTX71_13805)	2922146..2922646	-	501	WP_003112629.1	LEA type 2 family protein	-
MTX71_RS13840 (MTX71_13810)	2922747..2923367	+	621	WP_003101226.1	hypothetical protein	-
MTX71_RS13845 (MTX71_13815)	2923543..2923770	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MTX71_RS13850 (MTX71_13820)	2923767..2924048	+	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MTX71_RS13855 (MTX71_13825)	2924348..2925256	+	909	WP_003083769.1	LysR family transcriptional regulator	-
MTX71_RS13860 (MTX71_13830)	2925288..2925698	-	411	WP_003101225.1	aegerolysin family protein	-
MTX71_RS13865 (MTX71_13835)	2925878..2926612	-	735	WP_003117208.1	GntR family transcriptional regulator	-
MTX71_RS13870 (MTX71_13840)	2926713..2927399	-	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MTX71_RS13875 (MTX71_13845)	2927448..2928797	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T239998 WP_003083773.1 NZ_CP094677:2923767-2924048 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T239998 NZ_LS483444:c1645958-1645704 [Streptococcus australis]
ATGTTACTCAAGTTTACAGAAGATGCCTGGAAGGATTATTGTTACTGGCAAAGTCAGGACAAAAAAACACTGAAGCGGAT
TAATAGCCTGATTAAGGAGATTCAAAGGGATCCATTTGCAGGGATTGGTAAACCTGAACCCTTGAAATATGACTTTCAAG
GAGCATGGTCAAGGCGGATTGATGCAGAAAATCGCCTGATTTATATGCTAGATGAGTCAGGTGTCGCTTTCCTCTCTTTT
AAAGACCATTACTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT239998 WP_003083775.1 NZ_CP094677:2923543-2923770 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT239998 NZ_LS483444:c1646216-1645962 [Streptococcus australis]
ATGGAAGCAGTTGTTTATTCAACATTCCGCAATCATTTGAAGGATTATATGAAGAAGGTGAATGATGAGTTGGAGCCTTT
GACAGTCGTGAATAAGAATCCAGACGAAGATATTGTGGTTATTTCTAAGAGCGAGTGGGACAGCCTACAAGAAACCCTAA
GACTAGCTCAGAACAAAGAATTGTCAGATAAGGTCTTGCGGGGCATGGCAGAAGTCCGAGCTGGTCAGGTTCAACTCCAT
GAGATTGAGGGGTAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9