Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1164260..1165768 Replicon chromosome
Accession NZ_CP094677
Organism Pseudomonas aeruginosa strain Pa150

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag MTX71_RS05435 Protein ID WP_003119682.1
Coordinates 1165181..1165768 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9HYX2
Locus tag MTX71_RS05430 Protein ID WP_003115566.1
Coordinates 1164260..1165114 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX71_RS05415 (MTX71_05400) 1159679..1159888 + 210 WP_003091604.1 cold-shock protein -
MTX71_RS05420 (MTX71_05405) 1159949..1161823 - 1875 WP_003091605.1 MFS transporter -
MTX71_RS05425 (MTX71_05410) 1161998..1164163 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
MTX71_RS05430 (MTX71_05415) 1164260..1165114 - 855 WP_003115566.1 AraC family transcriptional regulator Antitoxin
MTX71_RS05435 (MTX71_05420) 1165181..1165768 - 588 WP_003119682.1 GNAT family protein Toxin
MTX71_RS05440 (MTX71_05425) 1166034..1169513 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T239997 WP_003119682.1 NZ_CP094677:c1165768-1165181 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T239997 NZ_LS483443:1838998-1840278 [Aggregatibacter segnis ATCC 33393]
ATGAGTAACTCGATTCTAAACGTCGCCATGAATGGCTTGTTAGTCGGTGAATGGCGAAAACTCACCAGTGGCGCAACCGA
ATTTCAGTATGCGGAAAAATGGCTTGAATCTGTTCGCTCGCGCCCTATTTCATTGTCACTGCCCTTGTCGCACAAAATTT
ATCGAGGAGATTCCGTTTACAATTTCTTCGATAATCTCCTCCCGGACAATGAGCAGATCCGTTCACGCATTCAGCAACGT
TTTCAAACCTCAACAAAATCCCCATTTGATTTACTTTCGGCGATTGGACAGGATTGTATCGGCGCAATTCAGCTTTATCA
GGGTGAGAACCGGTCGGTACGTCAAATTTATGCAGAACCGTTAAATGACAAAGAGGTGGAAAACGTGCTGAAAAACTACC
GCACTTTTCCTCTTGGTATGGAAGAAAGCGAGGATTTCCGAATTTCTTTAGCCGGCGCTCAGGAAAAAACAGCGCTGCTT
TATTATCAAAATCAATGGCAGCGCCCTTTGCATTCCACCGCGACCAGCCATATTTTTAAACTCCCGATTGGTATGGTGGC
ACAAGGGCAACTTGATCTTTCCGGTAGCTGTGAAAATGAATGGCTTTGCTTGAATATTATGAAAGCCTTCGGTTTGCCGG
TTCCTCGAAGCCAAATTCAGTATTTCGGTGAAATGAAAGTGCTGATTGTGGAGCGCTTCGATCGCCGTTGGTCTGAAAAT
AGAAGTTGGCTAATTCGTTTACCACAGGAGGATATGTGCCAAGCACTCAACATTGCCCCTGCGCGAAAATATGAAAATGA
CGGCGGGCCGAGCATTCTTCAAATTATGTCGCTTCTCAAGGGTTCATCCAACGCCCAAGCAGATCGCAAGCAGTTTTTTA
AAGCGCAAATTATTTTCTGGCTGCTTTGTGCCATTGACGGCCATGGCAAAAATTTCAGTCTATTTTTGGAACAAGAGAAT
CGCTATCGTCTAACGCCTTTTTATGACGTGATGTCCGCCTATCCGCTCATCAACCACAACGGACTACAAAAACAAAAAGT
CAAAATGGCAATGGCGTGGCACGGCAAAAATAAACATTATTTATGGGATAAAATACAACCCCGCCACATTTTCAACACCG
CTAAACTCGCAGGCTTGTCAAAGGAAACAGTTGAAGACGTTTTGCATGAGATCAGTGCGCTATATCGAAGAGTCAGTGAA
ATAAATACCCATGGATTGCCTGATGAAATTGTGGAGCCAATTTTAATGGGATTGGAAATGCAGATGAAAAAGATAAGTTA
A

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31933.23 Da        Isoelectric Point: 7.3276

>AT239997 WP_003115566.1 NZ_CP094677:c1165114-1164260 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT239997 NZ_LS483443:1838720-1838998 [Aggregatibacter segnis ATCC 33393]
ATGGTTATCACCACCGCAAAAATGCTTTCTCATGTAATTCGGGAATTTCGCTATCAAGGCGATCTGTCACAAACTGATGT
TGCTAAACTCGCCGGAACGACCCAAGCCCGAATTTCAGCGTTTGAGAATGAGCCGGAGCGTACTAAATTAGAAACGCTAT
TTAAAATTCTGGCAGGACTAGAACTAGAGCTTATTGTGCAACCACGCAAAAAGTCATCTAATACCGCTCTCTCAATTAAG
GAGCCAACAGCAACATACGATGACGATGAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB Q9HYX2

References