Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1234183..1234708 Replicon chromosome
Accession NZ_CP094676
Organism Streptomyces sp. CB09030

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L6J92_RS05665 Protein ID WP_224335784.1
Coordinates 1234183..1234446 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L6J92_RS05670 Protein ID WP_194276153.1
Coordinates 1234439..1234708 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6J92_RS05645 (L6J92_05645) 1229719..1230807 + 1089 WP_194276157.1 redox-regulated ATPase YchF -
L6J92_RS05650 (L6J92_05650) 1230935..1231327 - 393 WP_224335788.1 DNA-binding protein -
L6J92_RS05655 (L6J92_05655) 1231327..1231578 - 252 WP_164278816.1 hypothetical protein -
L6J92_RS05660 (L6J92_05660) 1231725..1233905 + 2181 WP_243780594.1 DEAD/DEAH box helicase -
L6J92_RS05665 (L6J92_05665) 1234183..1234446 - 264 WP_224335784.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6J92_RS05670 (L6J92_05670) 1234439..1234708 - 270 WP_194276153.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L6J92_RS05675 (L6J92_05675) 1235045..1235986 + 942 WP_243780595.1 helix-turn-helix transcriptional regulator -
L6J92_RS05680 (L6J92_05680) 1236052..1236966 + 915 WP_243780596.1 MBL fold metallo-hydrolase -
L6J92_RS05685 (L6J92_05685) 1236993..1238549 + 1557 WP_243780597.1 carboxylesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10087.58 Da        Isoelectric Point: 9.4306

>T239995 WP_224335784.1 NZ_CP094676:c1234446-1234183 [Streptomyces sp. CB09030]
VSEYRTVFRPEAQAELRKIPRDMALRILTKLTELESDPLGYSTTALVSQPERRRLRVGDYRVVYTIDKGELVVWVVHVGH
RSTVYEA

Download         Length: 264 bp

>T239995 NZ_LS483438:c1604876-1604628 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10286.78 Da        Isoelectric Point: 4.7574

>AT239995 WP_194276153.1 NZ_CP094676:c1234708-1234439 [Streptomyces sp. CB09030]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQIAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEEI
MRETLARGE

Download         Length: 270 bp

>AT239995 NZ_LS483438:c1604631-1604287 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References