Detailed information of TA system TA239994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 190381..191009
• Replicon: chromosome
• Accession: NZ_CP094676
• Organism: Streptomyces sp. CB09030

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L6J92_RS00915
• Protein ID: WP_243780232.1
• Coordinates: 190599..191009 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L6J92_RS00910
• Protein ID: WP_243780231.1
• Coordinates: 190381..190602 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6J92_RS00885 (L6J92_00885)	185668..186030	-	363	WP_224337520.1	hypothetical protein	-
L6J92_RS00890 (L6J92_00890)	186399..187214	+	816	WP_243780228.1	peptidoglycan-binding protein	-
L6J92_RS00895 (L6J92_00895)	187211..188107	+	897	WP_243780229.1	XRE family transcriptional regulator	-
L6J92_RS00900 (L6J92_00900)	188209..189348	-	1140	WP_243780230.1	NAD(P)/FAD-dependent oxidoreductase	-
L6J92_RS00905 (L6J92_00905)	189511..190203	-	693	WP_224295809.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
L6J92_RS00910 (L6J92_00910)	190381..190602	+	222	WP_243780231.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L6J92_RS00915 (L6J92_00915)	190599..191009	+	411	WP_243780232.1	PIN domain-containing protein	Toxin
L6J92_RS00925 (L6J92_00925)	191955..192530	+	576	WP_031043809.1	dCTP deaminase	-
L6J92_RS00930 (L6J92_00930)	192556..193053	+	498	WP_031043808.1	phosphoribosyltransferase	-
L6J92_RS00935 (L6J92_00935)	193121..194071	-	951	WP_224219989.1	Yip1 family protein	-
L6J92_RS00940 (L6J92_00940)	194197..195501	-	1305	WP_243782977.1	VCBS repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-42)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14957.58 Da
• Isoelectric Point: 5.4153

>T239994 WP_243780232.1 NZ_CP094676:190599-191009 [Streptomyces sp. CB09030]
VMYLLDTSGLVRLLRDANLQSAWHDAIDAGAIASCYVQRTEFLYSARNRSEYDEIAEMFSDLYPDAAVPKNAGRWISAVQ
HRMAQAGEHRSASAVDLVIAATAAHHGLTVLHDDADYGTVARHASDLNEHNVHEVV

Nucleotide

• Length: 411 bp

>T239994 NZ_LS483438:1222897-1223202 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8599.68 Da
• Isoelectric Point: 7.4051

>AT239994 WP_243780231.1 NZ_CP094676:190381-190602 [Streptomyces sp. CB09030]
MSVTQIDIDDEALERAMALAHVRTKKEAVNLALHFYAEQQERAARISRHFERAREWGAVEDAERLHRVEKRSR

Nucleotide

• Length: 222 bp

>AT239994 NZ_LS483438:1223213-1223536 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA