Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 190381..191009 Replicon chromosome
Accession NZ_CP094676
Organism Streptomyces sp. CB09030

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6J92_RS00915 Protein ID WP_243780232.1
Coordinates 190599..191009 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6J92_RS00910 Protein ID WP_243780231.1
Coordinates 190381..190602 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6J92_RS00885 (L6J92_00885) 185668..186030 - 363 WP_224337520.1 hypothetical protein -
L6J92_RS00890 (L6J92_00890) 186399..187214 + 816 WP_243780228.1 peptidoglycan-binding protein -
L6J92_RS00895 (L6J92_00895) 187211..188107 + 897 WP_243780229.1 XRE family transcriptional regulator -
L6J92_RS00900 (L6J92_00900) 188209..189348 - 1140 WP_243780230.1 NAD(P)/FAD-dependent oxidoreductase -
L6J92_RS00905 (L6J92_00905) 189511..190203 - 693 WP_224295809.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
L6J92_RS00910 (L6J92_00910) 190381..190602 + 222 WP_243780231.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L6J92_RS00915 (L6J92_00915) 190599..191009 + 411 WP_243780232.1 PIN domain-containing protein Toxin
L6J92_RS00925 (L6J92_00925) 191955..192530 + 576 WP_031043809.1 dCTP deaminase -
L6J92_RS00930 (L6J92_00930) 192556..193053 + 498 WP_031043808.1 phosphoribosyltransferase -
L6J92_RS00935 (L6J92_00935) 193121..194071 - 951 WP_224219989.1 Yip1 family protein -
L6J92_RS00940 (L6J92_00940) 194197..195501 - 1305 WP_243782977.1 VCBS repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-42)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14957.58 Da        Isoelectric Point: 5.4153

>T239994 WP_243780232.1 NZ_CP094676:190599-191009 [Streptomyces sp. CB09030]
VMYLLDTSGLVRLLRDANLQSAWHDAIDAGAIASCYVQRTEFLYSARNRSEYDEIAEMFSDLYPDAAVPKNAGRWISAVQ
HRMAQAGEHRSASAVDLVIAATAAHHGLTVLHDDADYGTVARHASDLNEHNVHEVV

Download         Length: 411 bp

>T239994 NZ_LS483438:1222897-1223202 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8599.68 Da        Isoelectric Point: 7.4051

>AT239994 WP_243780231.1 NZ_CP094676:190381-190602 [Streptomyces sp. CB09030]
MSVTQIDIDDEALERAMALAHVRTKKEAVNLALHFYAEQQERAARISRHFERAREWGAVEDAERLHRVEKRSR

Download         Length: 222 bp

>AT239994 NZ_LS483438:1223213-1223536 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References