Detailed information of TA system TA239993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 49374..49936
• Replicon: plasmid pCP113
• Accession: NZ_CP094667
• Organism: Gordonia amicalis strain G2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MTX80_RS23270
• Protein ID: WP_243829300.1
• Coordinates: 49646..49936 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MTX80_RS23265
• Protein ID: WP_243829299.1
• Coordinates: 49374..49649 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX80_RS23230 (MTX80_23230)	44620..44730	+	111	Protein_48	AAA family ATPase	-
MTX80_RS23235 (MTX80_23235)	44839..45048	+	210	WP_243829296.1	hypothetical protein	-
MTX80_RS23240 (MTX80_23240)	45226..46254	-	1029	WP_243829297.1	DUF4357 domain-containing protein	-
MTX80_RS23245 (MTX80_23245)	46942..47640	-	699	WP_243829298.1	DUF4190 domain-containing protein	-
MTX80_RS23250 (MTX80_23250)	47733..48116	-	384	Protein_52	sigma-70 family RNA polymerase sigma factor	-
MTX80_RS23255 (MTX80_23255)	48057..48473	+	417	WP_243829306.1	hypothetical protein	-
MTX80_RS23260 (MTX80_23260)	48854..49018	+	165	Protein_54	IS3 family transposase	-
MTX80_RS23265 (MTX80_23265)	49374..49649	+	276	WP_243829299.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MTX80_RS23270 (MTX80_23270)	49646..49936	+	291	WP_243829300.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTX80_RS23275 (MTX80_23275)	49979..50257	+	279	WP_007240633.1	hypothetical protein	-
MTX80_RS23280 (MTX80_23280)	50331..50840	+	510	Protein_58	transposase	-
MTX80_RS23285 (MTX80_23285)	51357..52271	+	915	WP_243829304.1	formylglycine-generating enzyme family protein	-
MTX80_RS23290 (MTX80_23290)	52268..54205	+	1938	WP_243829301.1	DNA topoisomerase (ATP-hydrolyzing) subunit B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..113941	113941

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (14-94)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10932.34 Da
• Isoelectric Point: 8.6441

>T239993 WP_243829300.1 NZ_CP094667:49646-49936 [Gordonia amicalis]
VSDNPTDSADEYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAGNPHRLSKPLRDDLEGLHSARRGDYRILLRIDDPHH
TIVIVKIDHRAHAYRT

Nucleotide

• Length: 291 bp

>T239993 NZ_LS483438:c705294-704890 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9756.01 Da
• Isoelectric Point: 4.4638

>AT239993 WP_243829299.1 NZ_CP094667:49374-49649 [Gordonia amicalis]
MTTVPLGEAKDKLSALIDSAESTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGIREAVAAADVEYAAGQTVSLE
DLRVEHGMPPQ

Nucleotide

• Length: 276 bp

>AT239993 NZ_LS483438:c705527-705291 [Haemophilus influenzae]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA