Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 859341..859833 Replicon chromosome
Accession NC_012925
Organism Streptococcus suis P1/7

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag SSU_RS04245 Protein ID WP_011922404.1
Coordinates 859341..859598 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag SSU_RS04250 Protein ID WP_012775104.1
Coordinates 859582..859833 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU_RS04225 854975..856045 + 1071 WP_012775436.1 tyrosine recombinase XerS -
SSU_RS04230 856115..857623 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
SSU_RS04235 857699..858640 - 942 WP_012775102.1 sensor histidine kinase -
SSU_RS04240 858637..859302 - 666 WP_012775103.1 response regulator transcription factor -
SSU_RS04245 859341..859598 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU_RS04250 859582..859833 - 252 WP_012775104.1 hypothetical protein Antitoxin
SSU_RS04255 859925..861895 - 1971 WP_012775105.1 FtsX-like permease family protein -
SSU_RS04260 861896..862648 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
SSU_RS04265 862784..863518 - 735 WP_011922410.1 ABC transporter permease -
SSU_RS04270 863520..864266 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T23999 WP_011922404.1 NC_012925:c859598-859341 [Streptococcus suis P1/7]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T23999 NC_012925:c859598-859341 [Streptococcus suis P1/7]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT23999 WP_012775104.1 NC_012925:c859833-859582 [Streptococcus suis P1/7]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT23999 NC_012925:c859833-859582 [Streptococcus suis P1/7]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References