Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1608768..1609282 Replicon chromosome
Accession NZ_CP094663
Organism Staphylococcus aureus strain 494

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MT995_RS08095 Protein ID WP_000581792.1
Coordinates 1608768..1608977 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MT995_RS08100 Protein ID WP_000138932.1
Coordinates 1608989..1609282 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT995_RS08075 (1604276) 1604276..1605634 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MT995_RS08080 (1605649) 1605649..1606719 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MT995_RS08085 (1607037) 1607037..1608239 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MT995_RS08090 (1608503) 1608503..1608640 - 138 WP_000828354.1 Lmo0850 family protein -
MT995_RS08095 (1608768) 1608768..1608977 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MT995_RS08100 (1608989) 1608989..1609282 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MT995_RS08105 (1609448) 1609448..1610932 + 1485 WP_000571549.1 cardiolipin synthase -
MT995_RS08110 (1610960) 1610960..1611607 + 648 WP_001187630.1 HD domain-containing protein -
MT995_RS08115 (1612520) 1612520..1613392 - 873 WP_000725802.1 membrane protein insertase YidC -
MT995_RS08120 (1613478) 1613478..1614119 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T239985 WP_000581792.1 NZ_CP094663:c1608977-1608768 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T239985 NZ_LS483429:1632221-1632559 [Haemophilus aegyptius]
GTGAAATTATCATTTATTGAATTACCGCCCTTTGAGCGTTACAGAAAAGCACATTTATCTGATGATGAATATAGGGCTTT
CCAGAATGAGCTATTAGAAAACCCTGAAAAGGGAGACGTGATACAAAATGCTGGTGGCTTGCGGAAAATTAGGATTGCCG
ATAGTGAAAGAAATAAAGGGAAACGAGGTGGCGCACGAGTGATTTATTACTATCTCATACGTAAATCGCAGATATTACTC
GTTACCGCTTACAGTAAAAACAGATGCGAAGATTTAACCACAGAGCAATATAAAATTTTAGCTAAACTGGTGAAAGAGAT
AGAGGAGCTAGAGCAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT239985 WP_000138932.1 NZ_CP094663:c1609282-1608989 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT239985 NZ_LS483429:1632556-1632864 [Haemophilus aegyptius]
ATGAGTAAATTATTTGATGAGCTTATAGAAGGGCTAAATGCCTATAAAGACTTTACACAGGGGAAAATAACGCTCAGAGT
AGAGACGCGTGAACGAATTGAACCTGCAAGCATTACAGCAGAGGAAGTGAAAGCAATTAGAGAGAAATTAAACCTTTCTC
AAGCCGTTTTTGCGCAGAAGTTACGAACTAGTGTAAGAACCTATCAAGGTTGGGAGCAAGGGAAAACCAAACCTAGCGCA
CACGCCTCCTTATTGTTGCGCATGGTGGATAAAGCCCCGCAAACCTTTGAGCTCATCGCAGGGATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References