Detailed information of TA system TA239984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1587509..1588038
• Replicon: chromosome
• Accession: NZ_CP094663
• Organism: Staphylococcus aureus strain 494

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MT995_RS07995
• Protein ID: WP_000621175.1
• Coordinates: 1587509..1587871 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: MT995_RS08000
• Protein ID: WP_000948331.1
• Coordinates: 1587868..1588038 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT995_RS07975 (1584487)	1584487..1585257	-	771	WP_001041111.1	RNA polymerase sigma factor SigB	-
MT995_RS07980 (1585232)	1585232..1585711	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
MT995_RS07985 (1585713)	1585713..1586039	-	327	WP_001052796.1	anti-sigma factor antagonist	-
MT995_RS07990 (1586158)	1586158..1587159	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
MT995_RS07995 (1587509)	1587509..1587871	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MT995_RS08000 (1587868)	1587868..1588038	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MT995_RS08005 (1588123)	1588123..1589271	-	1149	WP_001281153.1	alanine racemase	-
MT995_RS08010 (1589337)	1589337..1589696	-	360	WP_000581197.1	holo-ACP synthase	-
MT995_RS08015 (1589700)	1589700..1590191	-	492	WP_001205912.1	PH domain-containing protein	-
MT995_RS08020 (1590178)	1590178..1591761	-	1584	WP_001294626.1	PH domain-containing protein	-
MT995_RS08025 (1591754)	1591754..1592233	-	480	WP_001287087.1	hypothetical protein	-
MT995_RS08030 (1592441)	1592441..1593001	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T239984 WP_000621175.1 NZ_CP094663:c1587871-1587509 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T239984 NZ_LS483429:1458693-1459085 [Haemophilus aegyptius]
ATGTATATGTTAGATACGAATACTGTGAGTTATTTTTTCCGTAAAGTGCCTTCTGTAGTAGAACGATTAAGGCTGCTTAA
TCCTGAAATTCTCTGTATTTCTTCTGTTACCGCCGCTGAATTATTTTATGGTGTGGCAAAGCGTAATAATCTGCAACTTT
CACAGTTTCTAGATATATTTTTATCTGCGATTTCTATTTTAGAATGGGATACGAAAACCGCTGAAATTTATGGCAAGCTA
AGAGCTGAAATGGAAAAAGAAGGCAAAGTAATGGGCGTACAAGATCAGATGATTGCTGCTCACGCTTTAGCTAATGAATG
TGTTTTAGTCACGAGTGATAAAGCTTTTGAGTTTGTCCCCAACTTGATTTTAGAAAATTGGTGTAGTGTTTAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT239984 WP_000948331.1 NZ_CP094663:c1588038-1587868 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT239984 NZ_LS483429:1458432-1458692 [Haemophilus aegyptius]
ATGGAAAAAATCGCACGTTTATTTAGAAATGGTCGCAATCAAGCCGTTCGTTTACCTGTGGAATTTGAGTTTGACGCCAC
TCAAATTTATGTTTTCAAAGAAGAAAATGGCGATATTAGGCTTTCAACTCGTTCTCGTAGCCAGCAAAATTGGCAGAAAG
TCTTCGAATTGTTACCTACAATTCAATGTGATGAAGATTTTTTATCAGAAAAAGAGCGTAAGCAAGAAGTGGCAACGCGA
GATCCTTTTGAGGGCTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1