Detailed information of TA system TA239977

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 313166..313643
• Replicon: chromosome
• Accession: NZ_CP094663
• Organism: Staphylococcus aureus strain 494

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MT995_RS01480
• Protein ID: WP_000052076.1
• Coordinates: 313166..313354 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MT995_RS01485
• Protein ID: WP_001059690.1
• Coordinates: 313383..313643 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT995_RS01450 (309160)	309160..309681	+	522	WP_000824482.1	hypothetical protein	-
MT995_RS01455 (310022)	310022..310708	+	687	WP_000141557.1	thermonuclease family protein	-
MT995_RS01460 (311065)	311065..311265	+	201	WP_001059082.1	cold-shock protein	-
MT995_RS01465 (311757)	311757..311975	-	219	WP_000005886.1	hypothetical protein	-
MT995_RS01470 (312037)	312037..312321	-	285	WP_001004399.1	hypothetical protein	-
MT995_RS01475 (312409)	312409..312978	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
MT995_RS01480 (313166)	313166..313354	-	189	WP_000052076.1	hypothetical protein	Toxin
MT995_RS01485 (313383)	313383..313643	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MT995_RS01490 (313984)	313984..314187	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MT995_RS01495 (314184)	314184..314420	-	237	WP_000349581.1	hypothetical protein	-
MT995_RS01500 (314645)	314645..315226	+	582	WP_001140693.1	histidine phosphatase family protein	-
MT995_RS01505 (315299)	315299..315916	-	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
MT995_RS01510 (316071)	316071..316565	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MT995_RS01515 (316964)	316964..317386	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
MT995_RS01520 (317534)	317534..318250	+	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T239977 WP_000052076.1 NZ_CP094663:c313354-313166 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T239977 NZ_LS483424:2519995-2520177 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT239977 WP_001059690.1 NZ_CP094663:c313643-313383 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT239977 NZ_LS483424:2520200-2520589 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56