239976

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2469319..2469970 Replicon chromosome
Accession NZ_CP094661
Organism Lacticaseibacillus paracasei strain SCB0563

Toxin (Protein)


Gene name pemK Uniprot ID K6S8L5
Locus tag MRE03_RS11715 Protein ID WP_003567661.1
Coordinates 2469319..2469702 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID K6RKI5
Locus tag MRE03_RS11720 Protein ID WP_003567665.1
Coordinates 2469722..2469970 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRE03_RS11710 (MRE03_11710) 2468614..2469135 - 522 WP_003567657.1 QueT transporter family protein -
MRE03_RS11715 (MRE03_11715) 2469319..2469702 - 384 WP_003567661.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MRE03_RS11720 (MRE03_11720) 2469722..2469970 - 249 WP_003567665.1 antitoxin Antitoxin
MRE03_RS11725 (MRE03_11725) 2470038..2471174 - 1137 WP_003567667.1 alanine racemase -
MRE03_RS11730 (MRE03_11730) 2471161..2471535 - 375 WP_003567669.1 holo-ACP synthase -
MRE03_RS11735 (MRE03_11735) 2471704..2473212 - 1509 WP_013246091.1 DEAD/DEAH box helicase -
MRE03_RS11740 (MRE03_11740) 2473338..2473481 - 144 WP_003567673.1 hypothetical protein -
MRE03_RS11745 (MRE03_11745) 2473512..2474900 - 1389 WP_003567677.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13773.03 Da        Isoelectric Point: 10.9764

>T239976 WP_003567661.1 NZ_CP094661:c2469702-2469319 [Lacticaseibacillus paracasei]
MDVSVKRGDVFFADLSPVVGSEQGGNRPVLIIQNNVGNHYSPTVIVAAITSKIQKPKMPTHVGLRAKQDGVERNSVILLE
QIRTIDKQRLQARVTALSSTKMAAVDRALAISVGLVSLPKPKTYNKN

Download         Length: 384 bp

>T239976 NZ_LS483424:c1806732-1806421 [Bordetella parapertussis]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAACTGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8938.08 Da        Isoelectric Point: 4.4610

>AT239976 WP_003567665.1 NZ_CP094661:c2469970-2469722 [Lacticaseibacillus paracasei]
MKKQTSVAVTFDDAIKARLDAYCELNDIDAQAVITEAVATFLKSQAPEINQLISGYVAMGQINTEISHAFSACESEAYAH
IR

Download         Length: 249 bp

>AT239976 NZ_LS483424:c1806418-1806119 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K6S8L5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BNY2

References