Detailed information of TA system TA239974

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 1761596..1762116
• Replicon: chromosome
• Accession: NZ_CP094658
• Organism: Bifidobacterium longum subsp. infantis strain JRPT

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MT990_RS08145
• Protein ID: WP_243822303.1
• Coordinates: 1761862..1762116 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: -
• Locus tag: MT990_RS08140
• Protein ID: WP_243821462.1
• Coordinates: 1761596..1761862 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT990_RS08105 (MT990_08105)	1757498..1757752	+	255	Protein_1576	FctA domain-containing protein	-
MT990_RS08110 (MT990_08110)	1757828..1758454	+	627	WP_243821458.1	FctA domain-containing protein	-
MT990_RS08115 (MT990_08115)	1758787..1759425	+	639	WP_243821459.1	hypothetical protein	-
MT990_RS08120 (MT990_08120)	1759783..1760157	+	375	WP_243821460.1	hypothetical protein	-
MT990_RS08125 (MT990_08125)	1760173..1760514	-	342	WP_227484959.1	hypothetical protein	-
MT990_RS08130 (MT990_08130)	1760599..1761021	-	423	WP_243821461.1	hypothetical protein	-
MT990_RS08135 (MT990_08135)	1761044..1761424	-	381	WP_065472063.1	hypothetical protein	-
MT990_RS08140 (MT990_08140)	1761596..1761862	+	267	WP_243821462.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MT990_RS08145 (MT990_08145)	1761862..1762116	+	255	WP_243822303.1	Txe/YoeB family addiction module toxin	Toxin
MT990_RS08150 (MT990_08150)	1762110..1763174	-	1065	WP_243821463.1	hypothetical protein	-
MT990_RS08155 (MT990_08155)	1763257..1763637	-	381	WP_065436691.1	hypothetical protein	-
MT990_RS08160 (MT990_08160)	1763648..1764166	-	519	WP_065436692.1	hypothetical protein	-
MT990_RS08165 (MT990_08165)	1764423..1764683	+	261	WP_226746504.1	hypothetical protein	-
MT990_RS08170 (MT990_08170)	1764772..1766448	+	1677	WP_243821464.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1724071..1814277	90206

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-76)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9918.37 Da
• Isoelectric Point: 8.4862

>T239974 WP_243822303.1 NZ_CP094658:1761862-1762116 [Bifidobacterium longum subsp. infantis]
MLLCWTDDAWADYLYWQAQDRKTLKRVNTLIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCILSA
KDHY

Nucleotide

• Length: 255 bp

>T239974 NZ_LS483423:c1798434-1798180 [Jonesia denitrificans]
GTGCGGCTGGTTTGGGACGAGGCCGCCTGGGAGGACTACAAGCACTGGCAGACGGCCGACCGGAGGGTCCTCAAGCGGAT
CAACCTGCTCATTGACGCCTGCCTGCGCGAGCCGTTCGAGGGCATTGGCAAGCCTGAGCAGCTGAAGTACGGCGTGCAGG
GCTCGTGGTCCCGGCGGATCAATGAGGAGCACAGGCTCGTCTATCTCGTCGACGGCGACGATCTCGTGATCCTGCAGGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9850.07 Da
• Isoelectric Point: 4.3407

>AT239974 WP_243821462.1 NZ_CP094658:1761596-1761862 [Bifidobacterium longum subsp. infantis]
MTQAVGYSNFRANLKTYMRKVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQAMA
HDLVEAGA

Nucleotide

• Length: 267 bp

>AT239974 NZ_LS483423:c1798713-1798435 [Jonesia denitrificans]
ATGTCCATCAGCGCGAGCGAGGCCCGCAAGACGCTGTTTCCGCTCATCGAGCGCGTGAACCAGGATCACGAAGCTATCGA
GATCGTCTCCCGCAAGGGCAACGCGGTGCTCATGCCGGCCGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCGCCGGCGAACGCGCGCAGGCTGCTCGACGCCTACGACCGCGCCCGCGCCGGGAAGGTGCAGGCTCACGAACTCGAC
CGCTCCGACGAGCCCGCAGATCAGCCTCGGGGCATCTGA