Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1640560..1641109 Replicon chromosome
Accession NZ_CP094658
Organism Bifidobacterium longum subsp. infantis strain JRPT

Toxin (Protein)


Gene name mazF Uniprot ID B7GSS5
Locus tag MT990_RS07610 Protein ID WP_003833460.1
Coordinates 1640786..1641109 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0M4LW25
Locus tag MT990_RS07605 Protein ID WP_032743660.1
Coordinates 1640560..1640799 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT990_RS07590 (MT990_07590) 1636590..1637276 + 687 WP_234883588.1 TetR/AcrR family transcriptional regulator -
MT990_RS07595 (MT990_07595) 1637433..1638704 + 1272 WP_243821412.1 MFS transporter -
MT990_RS07600 (MT990_07600) 1639126..1640382 - 1257 WP_243821413.1 HipA domain-containing protein -
MT990_RS07605 (MT990_07605) 1640560..1640799 + 240 WP_032743660.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MT990_RS07610 (MT990_07610) 1640786..1641109 + 324 WP_003833460.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MT990_RS07615 (MT990_07615) 1641326..1641940 - 615 WP_003829107.1 cupin domain-containing protein -
MT990_RS07620 (MT990_07620) 1642035..1642904 - 870 WP_243821414.1 class I SAM-dependent methyltransferase -
MT990_RS07625 (MT990_07625) 1643142..1643507 + 366 WP_052789064.1 YccF domain-containing protein -
MT990_RS07630 (MT990_07630) 1644051..1645316 + 1266 WP_212105467.1 Fic family protein -
MT990_RS07635 (MT990_07635) 1645786..1646084 + 299 Protein_1488 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-54)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11829.64 Da        Isoelectric Point: 6.2932

>T239973 WP_003833460.1 NZ_CP094658:1640786-1641109 [Bifidobacterium longum subsp. infantis]
MKRGEIRTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

>T239973 NZ_LS483423:828035-828316 [Jonesia denitrificans]
GTGATCAGATCGTTCGGCGACAAGGAGACCGAACGGCTGTGGCGTCGTGAGCGCGTGCGCTCGATCGATCCGAGGATTCA
TCGGGTCGCGCTGCGCAAACTGCGTCAGGTGGGGTCCGCGGAGTCCATCGAGGACCTCCGTGTCCCACCCGGTAACCGCC
TCGAAGCTCTCAAGGGCAACCGATCTGGTCAGCACAGCATCAGGATCAACGACCAGTGGCGGATCTGCTTCGTGTGGACC
GCCGCCGGACCAGAGGAGGTGCAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9121.16 Da        Isoelectric Point: 4.5881

>AT239973 WP_032743660.1 NZ_CP094658:1640560-1640799 [Bifidobacterium longum subsp. infantis]
MQIATRVDDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDETR

Download         Length: 240 bp

>AT239973 NZ_LS483423:828303-828605 [Jonesia denitrificans]
TTGACTACCACTGACAAGATCGAGCCGATCCACCCGGGCGAGGTGCTCATGGAGGACTTCATCGAGGGCTTCGGCATCAC
GCAGAACAAGCTCGCCGTATCCATCGGCGTTCCGCCGCGACGGATCAACGAGATCGTGCACGGCAAGCGAGGGATCACCG
CAGACACGGCGCTGCGGCTCGCGAAGTACTTCGGCACCTCGGCCGAGTTCTGGATCAACCTGCAGAGCCACTACGAGCTG
GACCGTGCGGAGGACCTCGCGGGCGAGCAGATCGCGTCGATCACGCCACTGCAGGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0SL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0M4LW25

References