Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/DinJ(antitoxin) |
| Location | 1518206..1518839 | Replicon | chromosome |
| Accession | NZ_CP094658 | ||
| Organism | Bifidobacterium longum subsp. infantis strain JRPT | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | A0A0L7B5Y1 |
| Locus tag | MT990_RS06955 | Protein ID | WP_052789118.1 |
| Coordinates | 1518206..1518574 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | W6F017 |
| Locus tag | MT990_RS06960 | Protein ID | WP_025221597.1 |
| Coordinates | 1518555..1518839 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MT990_RS06910 (MT990_06910) | 1513606..1513863 | + | 258 | WP_131206856.1 | hypothetical protein | - |
| MT990_RS06915 (MT990_06915) | 1513860..1514372 | + | 513 | WP_243821377.1 | hypothetical protein | - |
| MT990_RS06920 (MT990_06920) | 1514369..1514923 | + | 555 | WP_052789123.1 | hypothetical protein | - |
| MT990_RS06925 (MT990_06925) | 1514994..1515509 | + | 516 | WP_052789122.1 | hypothetical protein | - |
| MT990_RS06930 (MT990_06930) | 1515506..1515772 | + | 267 | WP_243821378.1 | hypothetical protein | - |
| MT990_RS06935 (MT990_06935) | 1515930..1517174 | - | 1245 | WP_065456999.1 | Fic/DOC family N-terminal domain-containing protein | - |
| MT990_RS06940 (MT990_06940) | 1517255..1517398 | - | 144 | WP_234988953.1 | hypothetical protein | - |
| MT990_RS06945 (MT990_06945) | 1517388..1517621 | - | 234 | WP_052789120.1 | hypothetical protein | - |
| MT990_RS06950 (MT990_06950) | 1517618..1518016 | - | 399 | WP_052789119.1 | hypothetical protein | - |
| MT990_RS06955 (MT990_06955) | 1518206..1518574 | - | 369 | WP_052789118.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MT990_RS06960 (MT990_06960) | 1518555..1518839 | - | 285 | WP_025221597.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MT990_RS06965 (MT990_06965) | 1518912..1519214 | - | 303 | WP_052789117.1 | hypothetical protein | - |
| MT990_RS06970 (MT990_06970) | 1519302..1519484 | - | 183 | WP_052789116.1 | hypothetical protein | - |
| MT990_RS06975 (MT990_06975) | 1519484..1519825 | - | 342 | WP_052789115.1 | hypothetical protein | - |
| MT990_RS06980 (MT990_06980) | 1519828..1520679 | - | 852 | WP_052789114.1 | hypothetical protein | - |
| MT990_RS06985 (MT990_06985) | 1520877..1521218 | - | 342 | WP_052789113.1 | hypothetical protein | - |
| MT990_RS06990 (MT990_06990) | 1521332..1521676 | - | 345 | WP_014484967.1 | hypothetical protein | - |
| MT990_RS06995 (MT990_06995) | 1521673..1521834 | - | 162 | WP_155468229.1 | hypothetical protein | - |
| MT990_RS07000 (MT990_07000) | 1521924..1522538 | - | 615 | WP_052789112.1 | lysozyme | - |
| MT990_RS07005 (MT990_07005) | 1522751..1522978 | - | 228 | WP_025221588.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1496786..1553448 | 56662 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13824.67 Da Isoelectric Point: 4.5746
>T239971 WP_052789118.1 NZ_CP094658:c1518574-1518206 [Bifidobacterium longum subsp. infantis]
MTSTPSEPRLYDVWLMWVEFPDHPGIGKPRPVVITEVDGDLVSGIVAKITGNTDWDEAGDVPLLDWKAEGLAKPSLVRCS
QRFYFNRSELLQWFGRLSLRDAEHVNDGLEATLDIPPYRRSV
MTSTPSEPRLYDVWLMWVEFPDHPGIGKPRPVVITEVDGDLVSGIVAKITGNTDWDEAGDVPLLDWKAEGLAKPSLVRCS
QRFYFNRSELLQWFGRLSLRDAEHVNDGLEATLDIPPYRRSV
Download Length: 369 bp
>T239971 NZ_LS483422:4207173-4207433 [Providencia heimbachae]
ATGAGTAGGTTTTTAGCATGGACTGATCAAGCATGGGAAGACTACCTATATTGGCAAACTCAAGACAAAAAAACTCTCAA
ACGTATTAATAAGCTTATCGATGATACTAAAAGAACACCATTTTACGGAATAGGAAAGCCCGAGCCACTAAAAGAGAATT
TAGCTGGCTTCTGGTCTCGTAGAATAGATGAAACAAATAGGCTTATCTATTCAGTAGATGATACAAATTTAACTATTGTT
GCTTGTCGTTATCACTACTAA
ATGAGTAGGTTTTTAGCATGGACTGATCAAGCATGGGAAGACTACCTATATTGGCAAACTCAAGACAAAAAAACTCTCAA
ACGTATTAATAAGCTTATCGATGATACTAAAAGAACACCATTTTACGGAATAGGAAAGCCCGAGCCACTAAAAGAGAATT
TAGCTGGCTTCTGGTCTCGTAGAATAGATGAAACAAATAGGCTTATCTATTCAGTAGATGATACAAATTTAACTATTGTT
GCTTGTCGTTATCACTACTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10516.81 Da Isoelectric Point: 4.7309
>AT239971 WP_025221597.1 NZ_CP094658:c1518839-1518555 [Bifidobacterium longum subsp. infantis]
MGKLVANIDDDVKARAAALYDSMGMSLSTAVNMFLRQSLVDNGLPFKPTRHTPDGYPVPPVHNAYMFERSEKGHVILPAD
WNDSEDDVYDQYAK
MGKLVANIDDDVKARAAALYDSMGMSLSTAVNMFLRQSLVDNGLPFKPTRHTPDGYPVPPVHNAYMFERSEKGHVILPAD
WNDSEDDVYDQYAK
Download Length: 285 bp
>AT239971 NZ_LS483422:4206926-4207180 [Providencia heimbachae]
ATGAAAACTATTTCTTTCAGTGATGCTAGAAACAATCTAAAAGCAGTATTAGATAGAGTTGTTGATGACGCAGATACAAC
TATCATCACTCGTCGTGACTCAGAAGACGCTGTAGTGATGTCACTGGAATATTATAATAGCCTTATGGAAACGATTTATT
TATTACGTTCTCCAGCAAATGCCGAACATTTAAATAAATCCATCGCTCAATTTAAAGCAGGTAAAGCGAAAAAAAGAGAG
CTGATAAATGAGTAG
ATGAAAACTATTTCTTTCAGTGATGCTAGAAACAATCTAAAAGCAGTATTAGATAGAGTTGTTGATGACGCAGATACAAC
TATCATCACTCGTCGTGACTCAGAAGACGCTGTAGTGATGTCACTGGAATATTATAATAGCCTTATGGAAACGATTTATT
TATTACGTTCTCCAGCAAATGCCGAACATTTAAATAAATCCATCGCTCAATTTAAAGCAGGTAAAGCGAAAAAAAGAGAG
CTGATAAATGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0L7B5Y1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0L7B6S4 |