Detailed information of TA system TA239970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1394139..1394705
• Replicon: chromosome
• Accession: NZ_CP094658
• Organism: Bifidobacterium longum subsp. infantis strain JRPT

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MT990_RS06230
• Protein ID: WP_243821331.1
• Coordinates: 1394412..1394705 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0L7C7C8
• Locus tag: MT990_RS06225
• Protein ID: WP_014483711.1
• Coordinates: 1394139..1394408 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT990_RS06200 (MT990_06200)	1389609..1390016	-	408	WP_279576460.1	transposase	-
MT990_RS06205 (MT990_06205)	1390527..1392278	+	1752	WP_012577721.1	sodium:solute symporter family protein	-
MT990_RS06210 (MT990_06210)	1392312..1392653	+	342	WP_012577722.1	hypothetical protein	-
MT990_RS12730	1393004..1393129	-	126	WP_279576461.1	hypothetical protein	-
MT990_RS06215 (MT990_06215)	1393340..1393543	+	204	Protein_1206	hypothetical protein	-
MT990_RS06220 (MT990_06220)	1393540..1394091	+	552	WP_243821330.1	hypothetical protein	-
MT990_RS06225 (MT990_06225)	1394139..1394408	+	270	WP_014483711.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MT990_RS06230 (MT990_06230)	1394412..1394705	+	294	WP_243821331.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MT990_RS06235 (MT990_06235)	1394948..1395709	-	762	WP_007056226.1	IS21-like element ISBlo2 family helper ATPase IstB	-
MT990_RS06240 (MT990_06240)	1395706..1397190	-	1485	Protein_1211	IS21 family transposase	-
MT990_RS06245 (MT990_06245)	1397366..1397644	+	279	WP_243821332.1	hypothetical protein	-
MT990_RS06250 (MT990_06250)	1397648..1398097	+	450	WP_243821333.1	hypothetical protein	-
MT990_RS06255 (MT990_06255)	1398293..1398472	-	180	WP_101674037.1	antitoxin VbhA family protein	-
MT990_RS06260 (MT990_06260)	1398686..1399327	+	642	WP_154536509.1	moaA protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-85)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11321.03 Da
• Isoelectric Point: 8.1116

>T239970 WP_243821331.1 NZ_CP094658:1394412-1394705 [Bifidobacterium longum subsp. infantis]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNDVLECHIGNDGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Nucleotide

• Length: 294 bp

>T239970 NZ_LS483422:4206926-4207180 [Providencia heimbachae]
ATGAAAACTATTTCTTTCAGTGATGCTAGAAACAATCTAAAAGCAGTATTAGATAGAGTTGTTGATGACGCAGATACAAC
TATCATCACTCGTCGTGACTCAGAAGACGCTGTAGTGATGTCACTGGAATATTATAATAGCCTTATGGAAACGATTTATT
TATTACGTTCTCCAGCAAATGCCGAACATTTAAATAAATCCATCGCTCAATTTAAAGCAGGTAAAGCGAAAAAAAGAGAG
CTGATAAATGAGTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9860.17 Da
• Isoelectric Point: 4.7872

>AT239970 WP_014483711.1 NZ_CP094658:1394139-1394408 [Bifidobacterium longum subsp. infantis]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT239970 NZ_LS483422:4207173-4207433 [Providencia heimbachae]
ATGAGTAGGTTTTTAGCATGGACTGATCAAGCATGGGAAGACTACCTATATTGGCAAACTCAAGACAAAAAAACTCTCAA
ACGTATTAATAAGCTTATCGATGATACTAAAAGAACACCATTTTACGGAATAGGAAAGCCCGAGCCACTAAAAGAGAATT
TAGCTGGCTTCTGGTCTCGTAGAATAGATGAAACAAATAGGCTTATCTATTCAGTAGATGATACAAATTTAACTATTGTT
GCTTGTCGTTATCACTACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0L7C7C8