Detailed information of TA system TA239969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 1161550..1162403
• Replicon: chromosome
• Accession: NZ_CP094658
• Organism: Bifidobacterium longum subsp. infantis strain JRPT

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MT990_RS05105
• Protein ID: WP_243822181.1
• Coordinates: 1161912..1162403 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q8G4I4
• Locus tag: MT990_RS05100
• Protein ID: WP_011068030.1
• Coordinates: 1161550..1161912 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT990_RS05095 (MT990_05095)	1158705..1161404	+	2700	WP_243822180.1	aconitate hydratase AcnA	-
MT990_RS05100 (MT990_05100)	1161550..1161912	+	363	WP_011068030.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MT990_RS05105 (MT990_05105)	1161912..1162403	+	492	WP_243822181.1	PIN domain-containing protein	Toxin
MT990_RS05110 (MT990_05110)	1162463..1164568	-	2106	WP_243822182.1	DUF262 domain-containing protein	-
MT990_RS05115 (MT990_05115)	1164657..1165298	-	642	WP_013140893.1	GNAT family N-acetyltransferase	-
MT990_RS05120 (MT990_05120)	1165339..1165479	-	141	Protein_995	LuxR C-terminal-related transcriptional regulator	-
MT990_RS05125 (MT990_05125)	1165648..1166550	+	903	WP_243822183.1	Bax inhibitor-1/YccA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18370.99 Da
• Isoelectric Point: 4.5590

>T239969 WP_243822181.1 NZ_CP094658:1161912-1162403 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLLSSAIRREFKPNESEVENFTRSF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Nucleotide

• Length: 492 bp

>T239969 NZ_LS483422:c4003240-4002947 [Providencia heimbachae]
ATGATCTTTAATATTGAGTTTGATGAACGAGCCTTAAAGGAATGGAATAAACTTGATAGCAGTGTTAGAGAACAATTCAA
AAAAAAACTAAAAAAATTACAGACTAATCCTTATATTGAGTCAGCACGCTTGAATGGCGAGCAATCAAATTGCTATAAAA
TCAAGCTGCGTTCTTCTGGCTATCGTCTTGTTTATCAAATAATTGATTCAGAAATCGTCATTTTTGTTATTGCTATTGGT
AAAAGAGATGCCCAGAAAGCATATAAAGTAGCGAATATAAGACTAACGAAGTAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 14004.05 Da
• Isoelectric Point: 5.0733

>AT239969 WP_011068030.1 NZ_CP094658:1161550-1161912 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Nucleotide

• Length: 363 bp

>AT239969 NZ_LS483422:c4003484-4003230 [Providencia heimbachae]
ATGAGCACCATACAGATCAGAGTCGATGAACAATTAAAAAAAGATGCTTATCAAGCATTTGAAAAACTCAACTTATCTCC
ATCTGATGCATTAAGACTATTTTTACGCTATGTGGCAGAAAATGAAAAATTGCCCTTTTCTGAAGTATCTATCGTGGTGA
GTGAAAGTGATGATGATGATGCCATTTTGGCCGTTGTCCGTGAGCGTTTAAAAAAACCAGCAAAACGTATCAGAGTAAAT
GTGGATGATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S2W1N3