Detailed information of TA system TA239968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 14970..15535
• Replicon: chromosome
• Accession: NZ_CP094658
• Organism: Bifidobacterium longum subsp. infantis strain JRPT

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MT990_RS00055
• Protein ID: WP_243821813.1
• Coordinates: 14970..15260 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B7GSH1
• Locus tag: MT990_RS00060
• Protein ID: WP_012576473.1
• Coordinates: 15257..15535 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT990_RS00035 (MT990_00035)	10179..10745	+	567	WP_032743433.1	DUF3566 domain-containing protein	-
MT990_RS00040 (MT990_00040)	11391..12812	+	1422	WP_243821811.1	ATP-binding protein	-
MT990_RS00045 (MT990_00045)	12873..13097	-	225	WP_060620314.1	substrate-binding domain-containing protein	-
MT990_RS00050 (MT990_00050)	13246..14592	-	1347	WP_243821812.1	NADP-specific glutamate dehydrogenase	-
MT990_RS00055 (MT990_00055)	14970..15260	-	291	WP_243821813.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MT990_RS00060 (MT990_00060)	15257..15535	-	279	WP_012576473.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MT990_RS00065 (MT990_00065)	15838..16299	+	462	WP_243821814.1	hypothetical protein	-
MT990_RS00075 (MT990_00075)	16520..16771	-	252	Protein_13	transposase	-
MT990_RS00080 (MT990_00080)	17036..17680	+	645	WP_143723920.1	hypothetical protein	-
MT990_RS00085 (MT990_00085)	18102..18293	-	192	WP_243821815.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10827.49 Da
• Isoelectric Point: 9.9591

>T239968 WP_243821813.1 NZ_CP094658:c15260-14970 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSTLSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Nucleotide

• Length: 291 bp

>T239968 NZ_LS483422:2834873-2835181 [Providencia heimbachae]
ATGCAATATCACCTTTATCTAAATCGTGGCGATCGTATCCGGTACCCATATTTACTTGATATTCAAAGCGATATTATTGA
TATGCTCAATACTCGTCTCGTTATTCCTTTATATGATAGTAAACTTGTCCAGAAACCATTACCTGAACGATTAAATCCAA
TTATATACATCGATACCCATGCCTTTATTTTAATGACCCATCAAATGGCTTCAGTACCTCTATCTGTATTAGGAAAAAAA
GTTATCCATATTAAAAATGAAAGAGAAAAAATCAAACAAGCCATCGATTTGTTAATTGATGGATTTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10202.63 Da
• Isoelectric Point: 6.3216

>AT239968 WP_012576473.1 NZ_CP094658:c15535-15257 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Nucleotide

• Length: 279 bp

>AT239968 NZ_LS483422:2834634-2834873 [Providencia heimbachae]
ATGAGCTCTACAGCGCATAGAATGAAAAAAACCGTTAGTGTCACTGTGACACCTGAGTTATATGAACAAGCTAGACGCGC
TAAATTGAATTTCTCTGCTATTTTATCTAATGCTTTAATTATTGAGCTAAAAAAGGCTGAAGCATTAAAATGGAAAGAAC
AAAATAGAGAAGGTTTCAATGAGTTAAATAGAATAAGTGATGAAAATGGATTACTGTCCGATAAGTACAAGGAATTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0A8MHE5