Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1999331..2000967 Replicon chromosome
Accession NZ_CP094657
Organism Acinetobacter sp. XS-4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MMY79_RS09370 Protein ID WP_252613293.1
Coordinates 1999331..2000662 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MMY79_RS09375 Protein ID WP_199988203.1
Coordinates 2000659..2000967 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMY79_RS09340 (MMY79_09335) 1994962..1995837 + 876 WP_252613283.1 hypothetical protein -
MMY79_RS09345 (MMY79_09340) 1995827..1996054 + 228 WP_252613285.1 acyl carrier protein -
MMY79_RS09350 (MMY79_09345) 1996242..1997030 + 789 WP_252613287.1 PIG-L family deacetylase -
MMY79_RS09355 (MMY79_09350) 1997057..1997830 + 774 WP_252613289.1 formyltransferase family protein -
MMY79_RS09360 (MMY79_09355) 1997951..1998046 + 96 Protein_1824 hypothetical protein -
MMY79_RS09365 (MMY79_09360) 1998090..1999085 - 996 WP_252613291.1 putative multidrug efflux protein AdeT1 -
MMY79_RS09370 (MMY79_09365) 1999331..2000662 + 1332 WP_252613293.1 HipA domain-containing protein Toxin
MMY79_RS09375 (MMY79_09370) 2000659..2000967 + 309 WP_199988203.1 helix-turn-helix domain-containing protein Antitoxin
MMY79_RS09380 (MMY79_09375) 2001050..2001814 - 765 WP_252613295.1 isochorismatase family protein -
MMY79_RS09385 (MMY79_09380) 2001907..2002506 - 600 WP_252613297.1 dienelactone hydrolase family protein -
MMY79_RS09390 (MMY79_09385) 2002573..2002986 - 414 WP_252613299.1 DoxX family protein -
MMY79_RS09395 (MMY79_09390) 2003090..2003983 - 894 WP_252613300.1 LysR family transcriptional regulator -
MMY79_RS09400 (MMY79_09395) 2004113..2005183 - 1071 WP_252613302.1 two-component sensor histidine kinase AdeS -
MMY79_RS09405 (MMY79_09400) 2005214..2005957 - 744 WP_252613304.1 efflux system response regulator transcription factor AdeR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-357)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50703.48 Da        Isoelectric Point: 4.9647

>T239967 WP_252613293.1 NZ_CP094657:1999331-2000662 [Acinetobacter sp. XS-4]
MKKLTIQALLDASWLDIAELKLLESKQGSASASELEYELEYAIQHLDKRDEHACSLSLPVQILIKHESSTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPDSTLHLRYFSKEDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPDQKVWIDTYQENFDQPDQHYLVKFPRNKCSEIDCDIVRAEYYYYQILNELGFDTIETTQM
KLIEGTKYPSLWLPRFDTEWRNQQWHRHGLESVYSVLNKSSGSHLNHFEVIENLCNLLTHIDSDFDTSQFICEWLQRDLL
NIIFGNSDNHGGNTSFLKKSGKISLSPIYDFAPMKADPEVVIRSTTWGSPYEEGGEYRWVQITQKLAPWCDPDLSIGTLK
SLARNLVGLKQRLIDKGVPQQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T239967 NZ_LS483422:2333369-2333827 [Providencia heimbachae]
ATGATTTTATACCGGTTAATCAAATCTGATTTTGTACATGATGCATGGTCAGGGCAAGGTGCTCGATTATACGGTGGTCG
TTGGAATCATAAAGGAACCTCCGCAGTTTATGTCTCTACACAAATCTCTTTAGCTACTCTTGAAATACTGGTGCACCTTA
ATCAAGAGCGCTTATTGAATCATTATAATTTATTTTCAATTGAAATCAGCGATAAGCAAGTGATGAGGCTACCGTTAGAG
CATCTACCTGACGATTGGCAGAGTGATCCAGCCCCTACATCTACAATGGATATCGGCACCGCTTGGCTAACCGATAATGC
GAGTGTTGCACTACTGATCCCTTCTTGCGTGATCCCATATGAATATAATGCAATTATTAACCCGAACCATCCCCAATTTA
CTAAGGCAATCAATAGTATTAAACCGCTCGATTTTAGTTTTGATGCTCGGCTTAAATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11621.53 Da        Isoelectric Point: 9.9701

>AT239967 WP_199988203.1 NZ_CP094657:2000659-2000967 [Acinetobacter sp. XS-4]
INMKNQTQDRQQVLIDLYKQYLFNEITLGQLLTYLRKNVLSLSQEQYAALVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVGKIIKPSE

Download         Length: 309 bp

>AT239967 NZ_LS483422:2332908-2333372 [Providencia heimbachae]
ATGAGAAATTATATTCCCACCCTTCCTACCTCAAATATTGTATCGCCTACATTCAAACCACTGTGGCGCTTTGCAGGTTT
GCCTGCAGAAAGAGGCGTTGAACTCACTCACTTTTTACGCCAAGGGCTATCGGTCAACGTATTGGACAATATCCAAGAAT
GGTCAGGAATGAGTAAAGCAGAATTACTTCGCATATCCGGTATTAACGAACGTAATTTTGCTCGGCGTAAAAATGCCGGT
CAGCCACTTAATACGGATGAAAGTGAACGAATTGCGCGTTTAGTTCGTGTTTTTGATGCTGCAGTACGACTATTTAACGG
TGATAAGGTTGCGGCCAACGACTGGTTAAACCATCCGGTAAAAGGCTTAGGACATCTTCGTCCTATTGAATTAATTGCGA
CAGAAAGCGGGGCATTAGAGGTTATAGACCTTATCGGGCGCATCGAGCAGGGTGTCTTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References