Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1323558..1324192 Replicon chromosome
Accession NZ_CP094620
Organism Acinetobacter sp. NyZ410

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MTO68_RS06190 Protein ID WP_244015379.1
Coordinates 1323558..1323740 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A072CWY9
Locus tag MTO68_RS06195 Protein ID WP_034614020.1
Coordinates 1323782..1324192 (+) Length 137 a.a.

Genomic Context

MTO68_RS06175MTO68_RS06180MTO68_RS06185MTO68_RS06190MTO68_RS06195MTO68_RS06200MTO68_RS06205MTO68_RS06210
Location: 1319192..1320205 (1014 bp)
Type: Others
Protein ID: WP_244015376.1
Location: 1320208..1320819 (612 bp)
Type: Others
Protein ID: WP_244015377.1
Location: 1323090..1323317 (228 bp)
Type: Others
Protein ID: WP_244015378.1
Location: 1323558..1323740 (183 bp)
Type: Toxin
Protein ID: WP_244015379.1
Location: 1323782..1324192 (411 bp)
Type: Antitoxin
Protein ID: WP_034614020.1
Location: 1324645..1324815 (171 bp)
Type: Others
Protein ID: WP_244015380.1
Location: 1326612..1327145 (534 bp)
Type: Others
Protein ID: WP_004819818.1
Location: 1327225..1327953 (729 bp)
Type: Others
Protein ID: WP_004722241.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MTO68_RS06175 (MTO68_06175)1319192..1320205+1014WP_244015376.1type I-F CRISPR-associated protein Csy3-
MTO68_RS06180 (MTO68_06180)1320208..1320819+612WP_244015377.1type I-F CRISPR-associated endoribonuclease Cas6/Csy4-
MTO68_RS06185 (MTO68_06185)1323090..1323317+228WP_244015378.1DUF2188 domain-containing protein-
MTO68_RS06190 (MTO68_06190)1323558..1323740+183WP_244015379.1type II toxin-antitoxin system HicA family toxinToxin
MTO68_RS06195 (MTO68_06195)1323782..1324192+411WP_034614020.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
MTO68_RS06200 (MTO68_06200)1324645..1324815+171WP_244015380.1hypothetical protein-
MTO68_RS06205 (MTO68_06205)1326612..1327145+534WP_004819818.1fimbrial protein-
MTO68_RS06210 (MTO68_06210)1327225..1327953+729WP_004722241.1fimbria/pilus periplasmic chaperone-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6729.87 Da        Isoelectric Point: 10.1008

>T239961 WP_244015379.1 NZ_CP094620:1323558-1323740 [Acinetobacter sp. NyZ410]
MKSLELIKMIEADGWYEVRGKGSHHHFKHPTKEGLVTVPHPKKDLPTGTVKSILKQAGLE

Download         Length: 183 bp

>T239961 NZ_LS483420:1530990-1531325 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATCATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14885.87 Da        Isoelectric Point: 4.3885

>AT239961 WP_034614020.1 NZ_CP094620:1323782-1324192 [Acinetobacter sp. NyZ410]
MLYPIAVEKGSNDEAYGVIVPDIQGCFSAGDTFEEALSNAKEAIADHLEILAEDGKNIPLASEVSKFLNDEEFKGFIWAV
VEVDVNRYLGKAEKINVTLPSRLIYLIDDKVGKDKQYKSRSAFLAAGAEKILQASS

Download         Length: 411 bp

>AT239961 NZ_LS483420:1530713-1531000 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A072CWY9

References