Detailed information of TA system TA239961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1323558..1324192
• Replicon: chromosome
• Accession: NZ_CP094620
• Organism: Acinetobacter sp. NyZ410

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MTO68_RS06190
• Protein ID: WP_244015379.1
• Coordinates: 1323558..1323740 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A072CWY9
• Locus tag: MTO68_RS06195
• Protein ID: WP_034614020.1
• Coordinates: 1323782..1324192 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTO68_RS06175 (MTO68_06175)	1319192..1320205	+	1014	WP_244015376.1	type I-F CRISPR-associated protein Csy3	-
MTO68_RS06180 (MTO68_06180)	1320208..1320819	+	612	WP_244015377.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
MTO68_RS06185 (MTO68_06185)	1323090..1323317	+	228	WP_244015378.1	DUF2188 domain-containing protein	-
MTO68_RS06190 (MTO68_06190)	1323558..1323740	+	183	WP_244015379.1	type II toxin-antitoxin system HicA family toxin	Toxin
MTO68_RS06195 (MTO68_06195)	1323782..1324192	+	411	WP_034614020.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MTO68_RS06200 (MTO68_06200)	1324645..1324815	+	171	WP_244015380.1	hypothetical protein	-
MTO68_RS06205 (MTO68_06205)	1326612..1327145	+	534	WP_004819818.1	fimbrial protein	-
MTO68_RS06210 (MTO68_06210)	1327225..1327953	+	729	WP_004722241.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6729.87 Da
• Isoelectric Point: 10.1008

>T239961 WP_244015379.1 NZ_CP094620:1323558-1323740 [Acinetobacter sp. NyZ410]
MKSLELIKMIEADGWYEVRGKGSHHHFKHPTKEGLVTVPHPKKDLPTGTVKSILKQAGLE

Nucleotide

• Length: 183 bp

>T239961 NZ_LS483420:1530990-1531325 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATCATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14885.87 Da
• Isoelectric Point: 4.3885

>AT239961 WP_034614020.1 NZ_CP094620:1323782-1324192 [Acinetobacter sp. NyZ410]
MLYPIAVEKGSNDEAYGVIVPDIQGCFSAGDTFEEALSNAKEAIADHLEILAEDGKNIPLASEVSKFLNDEEFKGFIWAV
VEVDVNRYLGKAEKINVTLPSRLIYLIDDKVGKDKQYKSRSAFLAAGAEKILQASS

Nucleotide

• Length: 411 bp

>AT239961 NZ_LS483420:1530713-1531000 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A072CWY9