Detailed information of TA system TA239960

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4580..5108
• Replicon: plasmid pYH12068-4
• Accession: NZ_CP094559
• Organism: Acinetobacter sp. YH12068_T

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1I6WAN1
• Locus tag: MST18_RS16505
• Protein ID: WP_074947749.1
• Coordinates: 4815..5108 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MST18_RS16500
• Protein ID: WP_111885987.1
• Coordinates: 4580..4825 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MST18_RS16475 (MST18_16460)	1..951	+	951	WP_001208778.1	replication initiation protein RepM	-
MST18_RS16480 (MST18_16465)	944..1519	+	576	WP_002011656.1	plasmid replication DNA-binding protein	-
MST18_RS16485 (MST18_16470)	1540..1683	+	144	WP_001125247.1	hypothetical protein	-
MST18_RS16490 (MST18_16475)	1897..3465	-	1569	WP_159124549.1	ATP-binding cassette domain-containing protein	-
MST18_RS16495 (MST18_16480)	4205..4405	+	201	WP_163146734.1	hypothetical protein	-
MST18_RS16500 (MST18_16485)	4580..4825	+	246	WP_111885987.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MST18_RS16505 (MST18_16490)	4815..5108	+	294	WP_074947749.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MST18_RS16510 (MST18_16495)	5216..6381	+	1166	WP_119285041.1	IS3 family transposase	-
MST18_RS16515 (MST18_16500)	6421..6702	-	282	WP_257250405.1	hypothetical protein	-
MST18_RS16520 (MST18_16505)	6753..7972	+	1220	WP_180134041.1	IS3 family transposase	-
MST18_RS16525 (MST18_16510)	8273..10027	+	1755	WP_257250407.1	MobQ family relaxase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..10660	10660

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11280.47 Da
• Isoelectric Point: 10.4753

>T239960 WP_074947749.1 NZ_CP094559:4815-5108 [Acinetobacter sp. YH12068_T]
MTYKLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T239960 NZ_LS483418:c1804546-1804217 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9246.60 Da
• Isoelectric Point: 4.2821

>AT239960 WP_111885987.1 NZ_CP094559:4580-4825 [Acinetobacter sp. YH12068_T]
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRINDPKEMFEEITLDD
L

Nucleotide

• Length: 246 bp

>AT239960 NZ_LS483418:c1804823-1804536 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Structures

Toxin

• AlphaFold DB: A0A1I6WAN1