Detailed information of TA system TA239959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 43142..44477
• Replicon: plasmid pYH12068-2
• Accession: NZ_CP094557
• Organism: Acinetobacter sp. YH12068_T

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: MST18_RS16315
• Protein ID: WP_120376155.1
• Coordinates: 43142..44089 (-)
• Length: 316 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: MST18_RS16320
• Protein ID: WP_120376154.1
• Coordinates: 44082..44477 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MST18_RS16300 (MST18_16285)	39069..39443	-	375	WP_120376124.1	hypothetical protein	-
MST18_RS16305 (MST18_16290)	39719..40042	+	324	WP_120376123.1	hypothetical protein	-
MST18_RS16310 (MST18_16295)	40039..42906	+	2868	WP_180083592.1	relaxase/mobilization nuclease domain-containing protein	-
MST18_RS16315 (MST18_16300)	43142..44089	-	948	WP_120376155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MST18_RS16320 (MST18_16305)	44082..44477	-	396	WP_120376154.1	DUF6088 family protein	Antitoxin
MST18_RS16325 (MST18_16310)	46141..46662	-	522	Protein_49	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	floR / sul2 / tet(X6) / tet(Y) / dfrA1 / ant(3'')-Ia	-	1..61481	61481
	-	flank	IS/Tn	-	-	46123..46407	284

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-299)

Antitoxin

• Protein of unknown function DUF6088 (10-129)

Sequences

Toxin

Protein

• Length: 316 a.a.
• Molecular weight: 36241.70 Da
• Isoelectric Point: 6.3975

>T239959 WP_120376155.1 NZ_CP094557:c44089-43142 [Acinetobacter sp. YH12068_T]
MPDIKNVFADVADALGIGATSIVEKDYYVVELLRLLQSLEFETHDLVFAGGTSLAKANIQLNRMSEDVDIKIVPKPNIAL
SRSKAKVVRKQLLHQVQDKISQSDFFTIEEEPVVWDEYRYMELLIRYPQHFNQAPCLRPFIKLELVETDLLEPFESRSIT
SFVYDLAKKGKPVDAFPSVTIVSTSIEKLIAILRRTAAFARNAERADDESLVRHVYDYFKITYGKPQDFVYLGHLATKVI
KTDIERYGRQHTLMVEDPIAELLFGLNELSRNPLYKARFNNFVVPMVFGDKQISWQQAYSHFQDSVQQIFANLKL

Nucleotide

• Length: 948 bp

>T239959 NZ_LS483418:c1803417-1803160 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14884.31 Da
• Isoelectric Point: 10.6946

>AT239959 WP_120376154.1 NZ_CP094557:c44477-44082 [Acinetobacter sp. YH12068_T]
MTTKAKMQMRIKRSKRYVFMRDDFNDIANYDQIGRVLRNLVQEGELIKVGYGIYTKARKNQITGKVMPACPEGADAVILE
ALKRLDVQVTLGEATEKYLSGQSTQIPAFTQIKTPRRFTRQLSVGRSQINA

Nucleotide

• Length: 396 bp

>AT239959 NZ_LS483418:c1803679-1803419 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA