Detailed information of TA system TA239954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3170082..3170662
• Replicon: chromosome
• Accession: NZ_CP094545
• Organism: Acinetobacter sp. YH16056_T

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7H8SLW2
• Locus tag: MST17_RS15395
• Protein ID: WP_044425274.1
• Coordinates: 3170082..3170330 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A7H8SKS1
• Locus tag: MST17_RS15400
• Protein ID: WP_035270373.1
• Coordinates: 3170327..3170662 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MST17_RS15370 (MST17_15345)	3165495..3166592	-	1098	WP_180025892.1	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	-
MST17_RS15375 (MST17_15350)	3166895..3167839	-	945	WP_078190578.1	glutathione synthase	-
MST17_RS15380 (MST17_15355)	3168167..3169069	+	903	WP_180025891.1	sensor domain-containing diguanylate cyclase	-
MST17_RS15385 (MST17_15360)	3169195..3169392	+	198	WP_180025890.1	DUF3565 domain-containing protein	-
MST17_RS15390 (MST17_15365)	3169449..3169976	+	528	WP_000537572.1	plasmid pRiA4b ORF-3 family protein	-
MST17_RS15395 (MST17_15370)	3170082..3170330	+	249	WP_044425274.1	type II toxin-antitoxin system HicA family toxin	Toxin
MST17_RS15400 (MST17_15375)	3170327..3170662	+	336	WP_035270373.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MST17_RS15405 (MST17_15380)	3171167..3171439	-	273	WP_004641921.1	NadS family protein	-
MST17_RS15410 (MST17_15385)	3171432..3171752	-	321	WP_067765721.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MST17_RS15415 (MST17_15390)	3172003..3172227	+	225	WP_100329926.1	hypothetical protein	-
MST17_RS15420 (MST17_15395)	3172518..3173168	-	651	WP_078190583.1	orotate phosphoribosyltransferase	-
MST17_RS15425 (MST17_15400)	3173209..3174027	+	819	WP_180025889.1	exodeoxyribonuclease III	-
MST17_RS15430 (MST17_15405)	3174653..3175000	+	348	WP_180025888.1	Spx/MgsR family RNA polymerase-binding regulatory protein	-
MST17_RS15435 (MST17_15410)	3175105..3175542	-	438	WP_078190586.1	DUF2147 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-78)

Antitoxin

• Uncharacterised protein family HicB (54-102)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9451.04 Da
• Isoelectric Point: 10.3195

>T239954 WP_044425274.1 NZ_CP094545:3170082-3170330 [Acinetobacter sp. YH16056_T]
MGKTEKLLEKFGNSKNTFPYKDLVVLLNQLGYEKFEMAGSRVRFFNTKTEHMILLHRPHPENEIKGGALKSVKQALKQEG
FL

Nucleotide

• Length: 249 bp

>T239954 NZ_LS483417:c1145189-1144935 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12411.14 Da
• Isoelectric Point: 4.7146

>AT239954 WP_035270373.1 NZ_CP094545:3170327-3170662 [Acinetobacter sp. YH16056_T]
MSYLKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKTLEQAFQESVDGYLESCAELGKKPDQPFKGTFNVRISPE
LHRKAVLASSDNSLNAFVSDAIQEKLMRLGA

Nucleotide

• Length: 336 bp

>AT239954 NZ_LS483417:c1145433-1145191 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Toxin

• AlphaFold DB: A0A7H8SLW2

Antitoxin

• AlphaFold DB: A0A7H8SKS1