Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 743813..744462 Replicon chromosome
Accession NZ_CP094541
Organism Acinetobacter sp. YH16040_T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MST16_RS03520 Protein ID WP_180009879.1
Coordinates 744043..744462 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MST16_RS03515 Protein ID WP_078191134.1
Coordinates 743813..744043 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MST16_RS03505 (MST16_03500) 739778..742396 + 2619 WP_180009880.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
MST16_RS03510 (MST16_03505) 742567..743706 + 1140 WP_257222575.1 hypothetical protein -
MST16_RS03515 (MST16_03510) 743813..744043 + 231 WP_078191134.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MST16_RS03520 (MST16_03515) 744043..744462 + 420 WP_180009879.1 type II toxin-antitoxin system VapC family toxin Toxin
MST16_RS03525 (MST16_03520) 744595..744738 + 144 WP_078191132.1 zinc ribbon-containing protein -
MST16_RS03530 (MST16_03525) 744866..745441 + 576 WP_180009878.1 DUF4126 domain-containing protein -
MST16_RS03535 (MST16_03530) 745928..746137 + 210 WP_180009877.1 hypothetical protein -
MST16_RS03540 (MST16_03535) 746243..746500 + 258 WP_180009876.1 hypothetical protein -
MST16_RS03545 (MST16_03540) 747230..747472 + 243 WP_078191128.1 hypothetical protein -
MST16_RS03550 (MST16_03545) 747580..748281 + 702 Protein_686 DUF1003 domain-containing protein -
MST16_RS03555 (MST16_03550) 748889..749347 + 459 WP_180009875.1 GIY-YIG nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16181.61 Da        Isoelectric Point: 6.4895

>T239949 WP_180009879.1 NZ_CP094541:744043-744462 [Acinetobacter sp. YH16040_T]
MPTQYLLDTNICIYITKHQPEIVRQHFEKHLPDGNIFISVITLGELRFGAEKSQWKDKAFKVIDELTSIIPVIELDEHTA
VHYAQIRKQLALQGKMIGNNDLWLAAHARSNNWVMVTNNEKEFLRVDELQVENWLSKSL

Download         Length: 420 bp

>T239949 NZ_LS483413:c294884-294630 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTTTAATTTTACTGAAGAGGCTTGGGAAGATTACACTTCTTGGCAAAGAGAAGATAAAAAAAATCTCAAGCGTATTAA
TCGACTGATTGAAGATATCAAACGTCACCCTTTCGAAGGAATCGGAAAACCAGAACCTTTAAAATATCGGTATTCTGGTG
CCTGGTCTCGCCGTATTACAGACGAACACCGTCTCGTTTATACGGTAGAACAAAATGATATCTATTTCTTATCTTTTAGA
GATCACTATAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8995.26 Da        Isoelectric Point: 4.6936

>AT239949 WP_078191134.1 NZ_CP094541:743813-744043 [Acinetobacter sp. YH16040_T]
MTTAKVFMTGRSQAIRLPKEFRFEGKEVEIFRRGDEVILREKPVTADQLFKVLAQMPDDFYAETRVDEPPQEREEF

Download         Length: 231 bp

>AT239949 NZ_LS483413:c295143-294877 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGAAGCTGTTGTTTATTCAAATTTTAGAAACAATTTAAAAGATTACATGAAAAAGGTAAATGATGAATACGAGCCATT
AATGGTAGTTAATAAAAACCCTGAAGAAAATATCGTGGTCTTGTCTAAAGACAATTGGGATAGTATTCAAGAAACCATTC
GTATCATGAATAACGAATACCTCTCTGATAAAGTTCTATCAGGATTGGAACAAGTCAAACAAAAGAAAGTGACCCAACAC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References