Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 130416..130996 | Replicon | chromosome |
| Accession | NZ_CP094541 | ||
| Organism | Acinetobacter sp. YH16040_T | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A7H8SLW2 |
| Locus tag | MST16_RS00645 | Protein ID | WP_044425274.1 |
| Coordinates | 130416..130664 (+) | Length | 83 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A7H8SKS1 |
| Locus tag | MST16_RS00650 | Protein ID | WP_035270373.1 |
| Coordinates | 130661..130996 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MST16_RS00615 (MST16_00615) | 125419..126330 | - | 912 | WP_180008659.1 | alpha/beta hydrolase | - |
| MST16_RS00620 (MST16_00620) | 126486..126923 | + | 438 | WP_078193227.1 | DUF2147 domain-containing protein | - |
| MST16_RS00625 (MST16_00625) | 127028..127375 | - | 348 | WP_180008661.1 | Spx/MgsR family RNA polymerase-binding regulatory protein | - |
| MST16_RS00630 (MST16_00630) | 128005..128823 | - | 819 | WP_078193225.1 | exodeoxyribonuclease III | - |
| MST16_RS00635 (MST16_00635) | 128864..129514 | + | 651 | WP_078190583.1 | orotate phosphoribosyltransferase | - |
| MST16_RS00640 (MST16_00640) | 129783..130310 | + | 528 | WP_000537572.1 | plasmid pRiA4b ORF-3 family protein | - |
| MST16_RS00645 (MST16_00645) | 130416..130664 | + | 249 | WP_044425274.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MST16_RS00650 (MST16_00650) | 130661..130996 | + | 336 | WP_035270373.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MST16_RS00655 (MST16_00655) | 132092..132364 | - | 273 | WP_004641921.1 | NadS family protein | - |
| MST16_RS00660 (MST16_00660) | 132357..132677 | - | 321 | WP_067765721.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MST16_RS00665 (MST16_00665) | 132928..133152 | + | 225 | WP_100329926.1 | hypothetical protein | - |
| MST16_RS00670 (MST16_00670) | 133353..134678 | + | 1326 | WP_180012554.1 | ISNCY family transposase | - |
| MST16_RS00675 (MST16_00675) | 134729..134914 | - | 186 | Protein_129 | DUF3565 domain-containing protein | - |
| MST16_RS00680 (MST16_00680) | 135040..135942 | - | 903 | WP_180008762.1 | sensor domain-containing diguanylate cyclase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 133341..134678 | 1337 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9451.04 Da Isoelectric Point: 10.3195
>T239947 WP_044425274.1 NZ_CP094541:130416-130664 [Acinetobacter sp. YH16040_T]
MGKTEKLLEKFGNSKNTFPYKDLVVLLNQLGYEKFEMAGSRVRFFNTKTEHMILLHRPHPENEIKGGALKSVKQALKQEG
FL
MGKTEKLLEKFGNSKNTFPYKDLVVLLNQLGYEKFEMAGSRVRFFNTKTEHMILLHRPHPENEIKGGALKSVKQALKQEG
FL
Download Length: 249 bp
>T239947 NZ_LS483411:673047-673451 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTAGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTAGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG
Antitoxin
Download Length: 112 a.a. Molecular weight: 12411.14 Da Isoelectric Point: 4.7146
>AT239947 WP_035270373.1 NZ_CP094541:130661-130996 [Acinetobacter sp. YH16040_T]
MSYLKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKTLEQAFQESVDGYLESCAELGKKPDQPFKGTFNVRISPE
LHRKAVLASSDNSLNAFVSDAIQEKLMRLGA
MSYLKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKTLEQAFQESVDGYLESCAELGKKPDQPFKGTFNVRISPE
LHRKAVLASSDNSLNAFVSDAIQEKLMRLGA
Download Length: 336 bp
>AT239947 NZ_LS483411:672814-673050 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7H8SLW2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7H8SKS1 |