Detailed information of TA system TA239946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 1839062..1839627
• Replicon: chromosome
• Accession: NZ_CP094534
• Organism: Hymenobacter monticola strain KACC 22596

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MTP16_RS07730
• Protein ID: WP_243517743.1
• Coordinates: 1839062..1839406 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MTP16_RS07735
• Protein ID: WP_243517745.1
• Coordinates: 1839403..1839627 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP16_RS07700 (MTP16_07700)	1835709..1836455	+	747	WP_243517731.1	abortive infection family protein	-
MTP16_RS07705 (MTP16_07705)	1836514..1836873	+	360	WP_243517733.1	YbbC/YhhH family protein	-
MTP16_RS07710 (MTP16_07710)	1837025..1837483	+	459	WP_243517735.1	SUKH-3 domain-containing protein	-
MTP16_RS07715 (MTP16_07715)	1837626..1837961	+	336	WP_243517737.1	hypothetical protein	-
MTP16_RS07720 (MTP16_07720)	1838204..1838515	+	312	WP_243517739.1	hypothetical protein	-
MTP16_RS07725 (MTP16_07725)	1838657..1839007	+	351	WP_243517741.1	YbbC/YhhH family protein	-
MTP16_RS07730 (MTP16_07730)	1839062..1839406	-	345	WP_243517743.1	DUF5615 family PIN-like protein	Toxin
MTP16_RS07735 (MTP16_07735)	1839403..1839627	-	225	WP_243517745.1	DUF433 domain-containing protein	Antitoxin
MTP16_RS07740 (MTP16_07740)	1840302..1840607	+	306	WP_243517749.1	NTF2 fold immunity protein	-
MTP16_RS07745 (MTP16_07745)	1840909..1841616	+	708	WP_243517751.1	hypothetical protein	-
MTP16_RS07750 (MTP16_07750)	1841822..1842829	-	1008	WP_243517753.1	hypothetical protein	-
MTP16_RS07755 (MTP16_07755)	1842933..1843037	+	105	Protein_1533	FMN-dependent NADH-azoreductase	-
MTP16_RS07760 (MTP16_07760)	1843125..1844027	+	903	WP_243517755.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (1-78)

Antitoxin

• Protein of unknown function DUF433 (8-63)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12588.64 Da
• Isoelectric Point: 4.3885

>T239946 WP_243517743.1 NZ_CP094534:c1839406-1839062 [Hymenobacter monticola]
MTIWIDAHLSPLIAAWIKWKFPVEAVALRTLGLRDAEDEEIFRAAKAAGAVVLTKDADFRQLLDRFGPPPQIIWLTCGNT
SNERLQEVLLATLPAAIELLEAGEPFVEIGNVLP

Nucleotide

• Length: 345 bp

>T239946 NZ_LS483411:331553-331912 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTTAAACATTTAGACGGTGAAATTTGGGAACTTCGCCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8181.48 Da
• Isoelectric Point: 7.1330

>AT239946 WP_243517745.1 NZ_CP094534:c1839627-1839403 [Hymenobacter monticola]
MESLQHRITTNPRQCGGRPCIRGMRIRVADVLQLFAAGLTAEQILGEMPDLEALDLQAALQYAARQIDHPRLAA

Nucleotide

• Length: 225 bp

>AT239946 NZ_LS483411:331905-332201 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTACGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAACAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA