Detailed information of TA system TA239945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1272910..1273497
• Replicon: chromosome
• Accession: NZ_CP094532
• Organism: Chryseobacterium suipulveris strain SC2-2

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: MTP09_RS06005
• Protein ID: WP_243551158.1
• Coordinates: 1273198..1273497 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8WVU0
• Locus tag: MTP09_RS06000
• Protein ID: WP_055041555.1
• Coordinates: 1272910..1273194 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP09_RS05970 (MTP09_05970)	1268737..1269612	-	876	WP_243551149.1	hypothetical protein	-
MTP09_RS05975 (MTP09_05975)	1269781..1271079	-	1299	WP_243551150.1	hypothetical protein	-
MTP09_RS05980 (MTP09_05980)	1271272..1271751	-	480	WP_243551151.1	hypothetical protein	-
MTP09_RS05985 (MTP09_05985)	1271888..1272118	-	231	WP_243551153.1	hypothetical protein	-
MTP09_RS05990 (MTP09_05990)	1272190..1272396	+	207	WP_243551154.1	hypothetical protein	-
MTP09_RS05995 (MTP09_05995)	1272396..1272671	+	276	WP_243551156.1	hypothetical protein	-
MTP09_RS06000 (MTP09_06000)	1272910..1273194	-	285	WP_055041555.1	putative addiction module antidote protein	Antitoxin
MTP09_RS06005 (MTP09_06005)	1273198..1273497	-	300	WP_243551158.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTP09_RS06010 (MTP09_06010)	1274334..1275848	-	1515	WP_243551160.1	hypothetical protein	-
MTP09_RS06015 (MTP09_06015)	1276076..1276771	-	696	WP_243551162.1	hypothetical protein	-
MTP09_RS06020 (MTP09_06020)	1277045..1278172	-	1128	WP_124643211.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1232815..1315318	82503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (6-91)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11784.73 Da
• Isoelectric Point: 10.0546

>T239945 WP_243551158.1 NZ_CP094532:c1273497-1273198 [Chryseobacterium suipulveris]
MYFIEKTNEFDKWFRKLKDIRAKAKILFRIQKLQNEEHFGDCKPVGNGISELRINFAKGYRIYFKETDGKIIILLIGGDK
SSQQKDIEKAKEIWEKVKE

Nucleotide

• Length: 300 bp

>T239945 NZ_LS483411:247979-248287 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10136.69 Da
• Isoelectric Point: 4.2958

>AT239945 WP_055041555.1 NZ_CP094532:c1273194-1272910 [Chryseobacterium suipulveris]
MDISKFDIADYLDSNEMIAEYLNVVLEEGDDSEIVVAIGNIAKAIGMTKIAEETGMSRPSLYKALSEGAKPQFSTIMKVL
KAVGGQIRVNPITA

Nucleotide

• Length: 285 bp

>AT239945 NZ_LS483411:247683-247979 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A3G8WVU0