Detailed information of TA system TA239944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 7854241..7854829
• Replicon: chromosome
• Accession: NZ_CP094526
• Organism: Bradyrhizobium sp. ISRA464

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MTX19_RS36410
• Protein ID: WP_280981501.1
• Coordinates: 7854476..7854829 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: MTX19_RS36405
• Protein ID: WP_280981500.1
• Coordinates: 7854241..7854495 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX19_RS36370 (MTX19_36190)	7849270..7849500	+	231	WP_280981493.1	hypothetical protein	-
MTX19_RS36375 (MTX19_36195)	7849651..7849947	+	297	WP_280981494.1	hypothetical protein	-
MTX19_RS36380 (MTX19_36200)	7849937..7850509	+	573	WP_280981495.1	hypothetical protein	-
MTX19_RS36385 (MTX19_36205)	7851354..7852010	+	657	WP_280981496.1	phosphoribosylanthranilate isomerase	-
MTX19_RS36390 (MTX19_36210)	7852386..7852571	-	186	WP_280981497.1	hypothetical protein	-
MTX19_RS36395 (MTX19_36215)	7852885..7853145	+	261	WP_280981498.1	hypothetical protein	-
MTX19_RS36400 (MTX19_36220)	7853386..7853718	-	333	WP_280981499.1	hypothetical protein	-
MTX19_RS36405 (MTX19_36225)	7854241..7854495	+	255	WP_280981500.1	hypothetical protein	Antitoxin
MTX19_RS36410 (MTX19_36230)	7854476..7854829	+	354	WP_280981501.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MTX19_RS36415 (MTX19_36235)	7854898..7855509	+	612	WP_280981502.1	hypothetical protein	-
MTX19_RS36420 (MTX19_36240)	7855566..7857221	-	1656	WP_280985726.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (12-113)

Antitoxin

• Antitoxin PemI-like (1-84)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 12706.43 Da
• Isoelectric Point: 6.0653

>T239944 WP_280981501.1 NZ_CP094526:7854476-7854829 [Bradyrhizobium sp. ISRA464]
MATKSGNYCPEAGDFVWIDLDPTIGHEQSGRRPAIVLSPHNYNAAAGLCVICPITSSVRDYPFEAKLPDGASFHGVVLAD
QPRSISWEKRPIQHAGRAPDVLLTEVRERLAALLGID

Nucleotide

• Length: 354 bp

>T239944 NZ_LS483411:c183446-183168 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAAGGTGTTCAGCAGGCTTATACAGA
CATTGGTGCGGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATACAAATGAAGATATGGCAA
ACCTTTTTCAGGCAATGAATGAACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGACTTCACTGACTTTATACGAAGTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9390.76 Da
• Isoelectric Point: 10.1998

>AT239944 WP_280981500.1 NZ_CP094526:7854241-7854495 [Bradyrhizobium sp. ISRA464]
MKVAFQKWGNSLALRVPKAFADEIGASDGKAAEMTVSDGKLVIEIARSPRRKRRYALDKLVAGITPDNRHEEVDWGRPIG
NEVW

Nucleotide

• Length: 255 bp

>AT239944 NZ_LS483411:c183646-183455 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGATATTTATCGCTTAT
CTCACTTACTTGAAGATCCCGAAGCTGAATAA